| 9/5/2016 | Mississippi (5-7) | 34 | vs | Florida State | 45 | Orlando FL | SEC | |
| 9/10/2016 | Charleston Southern (7-4) | 8 | at | Florida State | 52 | BigS (1AA) | ||
| 9/17/2016 | Florida State | 20 | at | Louisville (9-4,7-1) | 63 | |||
| 9/24/2016 | Florida State | 55 | at | South Florida (11-2) | 35 | at AAC | ||
| 10/1/2016 | North Carolina (8-5,5-3) | 37 | at | Florida State | 35 | |||
| 10/8/2016 | Florida State | 20 | at | Miami-Florida (9-4,5-3) | 19 | |||
| 10/15/2016 | Wake Forest (7-6,3-5) | 6 | at | Florida State | 17 | |||
| 10/29/2016 | Clemson (14-1,8-1) | 37 | at | Florida State | 34 | |||
| 11/5/2016 | Florida State | 24 | at | North Carolina State (7-6,3-5) | 20 | |||
| 11/11/2016 | Boston College (7-6,2-6) | 7 | at | Florida State | 45 | |||
| 11/19/2016 | Florida State | 45 | at | Syracuse (4-8,2-6) | 14 | |||
| 11/26/2016 | Florida (9-4) | 13 | at | Florida State | 31 | SEC | ||
| 12/30/2016 | Michigan (10-3) | 32 | vs | Florida State | 33 | Orange Bowl (Miami FL) | B10 |
| vs Florida State | vs Other Opponents | Florida State compared to OOs | |
| Record: | 3-10 | 104-50 | |
| Points Scored: | 25.00 | 32.66 | 7.66 |
| Points Allowed: | 35.08 | 22.88 | 12.20 |
| Margin: | -10.08 | 9.78 | 19.86 |
| Total Points: | 60.08 | 55.54 | 4.54 |