| 9/3/2016 | North Carolina Central (9-3) | 6 | at | Duke | 49 | MEAC (1AA) | ||
| 9/10/2016 | Wake Forest (7-6,3-5) | 24 | at | Duke | 14 | |||
| 9/17/2016 | Duke | 13 | at | Northwestern (7-6) | 24 | at B10 | ||
| 9/24/2016 | Duke | 38 | at | Notre Dame (4-8) | 35 | at ND | ||
| 10/1/2016 | Virginia (2-10,1-7) | 34 | at | Duke | 20 | |||
| 10/8/2016 | Army (8-5) | 6 | at | Duke | 13 | Ind | ||
| 10/14/2016 | Duke | 14 | at | Louisville (9-4,7-1) | 24 | |||
| 10/29/2016 | Duke | 35 | at | Georgia Tech (9-4,4-4) | 38 | |||
| 11/5/2016 | Virginia Tech (10-4,6-3) | 24 | at | Duke | 21 | |||
| 11/10/2016 | North Carolina (8-5,5-3) | 27 | at | Duke | 28 | |||
| 11/19/2016 | Duke | 14 | at | Pittsburgh (8-5,5-3) | 56 | |||
| 11/26/2016 | Duke | 21 | at | Miami-Florida (9-4,5-3) | 40 |
| vs Duke | vs Other Opponents | Duke compared to OOs | |
| Record: | 8-4 | 82-60 | |
| Points Scored: | 28.17 | 31.34 | 3.17 |
| Points Allowed: | 23.33 | 24.92 | -1.59 |
| Margin: | 4.84 | 6.42 | 1.58 |
| Total Points: | 51.50 | 56.26 | -4.76 |