| 9/1/2016 | Tulane (4-8) | 3 | at | Wake Forest | 7 | AAC | ||
| 9/10/2016 | Wake Forest | 24 | at | Duke (4-8,1-7) | 14 | |||
| 9/17/2016 | Delaware (4-7) | 21 | at | Wake Forest | 38 | CAAF (1AA) | ||
| 9/24/2016 | Wake Forest | 33 | at | Indiana (6-7) | 28 | at B10 | ||
| 10/1/2016 | Wake Forest | 16 | at | North Carolina State (7-6,3-5) | 33 | |||
| 10/8/2016 | Syracuse (4-8,2-6) | 9 | at | Wake Forest | 28 | |||
| 10/15/2016 | Wake Forest | 6 | at | Florida State (10-3,5-3) | 17 | |||
| 10/29/2016 | Army (8-5) | 21 | at | Wake Forest | 13 | Ind | ||
| 11/5/2016 | Virginia (2-10,1-7) | 20 | at | Wake Forest | 27 | |||
| 11/12/2016 | Wake Forest | 12 | at | Louisville (9-4,7-1) | 44 | |||
| 11/19/2016 | Clemson (14-1,8-1) | 35 | at | Wake Forest | 13 | |||
| 11/26/2016 | Boston College (7-6,2-6) | 17 | at | Wake Forest | 14 | |||
| 12/27/2016 | Temple (10-4) | 26 | vs | Wake Forest | 34 | Military Bowl (Annapolis MD) | AAC |
| vs Wake Forest | vs Other Opponents | Wake Forest compared to OOs | |
| Record: | 6-7 | 83-70 | |
| Points Scored: | 22.15 | 29.35 | 7.20 |
| Points Allowed: | 20.38 | 25.78 | -5.40 |
| Margin: | 1.77 | 3.57 | 1.80 |
| Total Points: | 42.53 | 55.13 | -12.60 |