| 9/3/2016 | Murray State | 3 | at | Illinois (3-9) | 52 | at B10 | ||
| 9/10/2016 | Missouri State (4-7) | 28 | at | Murray State | 22 | MVC | ||
| 9/17/2016 | Murray State | 17 | at | Southern Illinois (4-7) | 50 | at MVC | ||
| 9/24/2016 | SE Missouri State (3-8,3-5) | 17 | at | Murray State | 16 | |||
| 10/1/2016 | Murray State | 45 | at | Austin Peay (0-11,0-8) | 17 | |||
| 10/15/2016 | Tennessee-Martin (7-5,6-2) | 38 | at | Murray State | 31 | |||
| 10/22/2016 | Murray State | 40 | at | Eastern Illinois (6-5,4-4) | 38 | |||
| 10/29/2016 | Tennessee State (7-4,4-3) | 31 | at | Murray State | 38 | |||
| 11/5/2016 | Murray State | 41 | at | Eastern Kentucky (3-8,2-6) | 28 | |||
| 11/12/2016 | Jacksonville State (10-2,7-0) | 33 | at | Murray State | 15 | |||
| 11/19/2016 | Murray State | 19 | at | Tennessee Tech (5-6,5-3) | 55 |
| vs Murray State | vs Other Opponents | Murray State compared to OOs | |
| Record: | 7-4 | 45-68 | |
| Points Scored: | 35.18 | 25.88 | -9.30 |
| Points Allowed: | 26.09 | 30.19 | -4.10 |
| Margin: | 9.09 | -4.31 | -13.40 |
| Total Points: | 61.27 | 56.07 | 5.20 |