| 9/2/2016 | Colorado State (7-6) | 7 | vs | Colorado | 44 | | Denver CO | MW |
| 9/10/2016 | Idaho State (2-9) | 7 | at | Colorado | 56 | | | BSky (1AA) |
| 9/17/2016 | Colorado | 28 | at | Michigan (10-3) | 45 | | | at B10 |
| 9/24/2016 | Colorado | 41 | at | Oregon (4-8,2-7) | 38 | | | |
| 10/1/2016 | Oregon State (4-8,3-6) | 6 | at | Colorado | 47 | | | |
| 10/8/2016 | Colorado | 17 | at | Southern California (10-3,7-2) | 21 | | | |
| 10/15/2016 | Arizona State (5-7,2-7) | 16 | at | Colorado | 40 | | | |
| 10/22/2016 | Colorado | 10 | at | Stanford (10-3,6-3) | 5 | | | |
| 11/3/2016 | UCLA (4-8,2-7) | 10 | at | Colorado | 20 | | | |
| 11/12/2016 | Colorado | 49 | at | Arizona (3-9,1-8) | 24 | | | |
| 11/19/2016 | Washington State (8-5,7-2) | 24 | at | Colorado | 38 | | | |
| 11/26/2016 | Utah (9-4,5-4) | 22 | at | Colorado | 27 | | | |
| 12/2/2016 | Colorado | 10 | vs | Washington (12-2,9-1) | 41 | | Santa Clara CA | |
| 12/29/2016 | Oklahoma State (10-3) | 38 | vs | Colorado | 8 | | Alamo Bowl (San Antonio TX) | B12 |