| 9/3/2016 | Northern Illinois (5-7) | 34 | at | Wyoming | 40 | OT | MAC | |
| 9/10/2016 | Wyoming | 17 | at | Nebraska (9-4) | 52 | at B10 | ||
| 9/17/2016 | UC Davis (3-8) | 22 | at | Wyoming | 45 | BSky (1AA) | ||
| 9/23/2016 | Wyoming | 24 | at | Eastern Michigan (7-6) | 27 | at MAC | ||
| 10/1/2016 | Wyoming | 38 | at | Colorado State (7-6,5-3) | 17 | |||
| 10/8/2016 | Air Force (10-3,5-3) | 26 | at | Wyoming | 35 | |||
| 10/22/2016 | Wyoming | 42 | at | Nevada (5-7,3-5) | 34 | |||
| 10/29/2016 | Boise State (10-3,6-2) | 28 | at | Wyoming | 30 | |||
| 11/5/2016 | Utah State (3-9,1-7) | 28 | at | Wyoming | 52 | |||
| 11/12/2016 | Wyoming | 66 | at | UNLV (4-8,3-5) | 69 | 3OT | ||
| 11/19/2016 | San Diego State (11-3,7-2) | 33 | at | Wyoming | 34 | |||
| 11/26/2016 | Wyoming | 35 | at | New Mexico (9-4,6-2) | 56 | |||
| 12/3/2016 | San Diego State (11-3,7-2) | 27 | at | Wyoming | 24 | |||
| 12/21/2016 | BYU (9-4) | 24 | vs | Wyoming | 21 | Poinsettia Bowl (San Diego) | Ind |
| vs Wyoming | vs Other Opponents | Wyoming compared to OOs | |
| Record: | 6-8 | 96-66 | |
| Points Scored: | 34.07 | 31.49 | -2.58 |
| Points Allowed: | 35.93 | 27.02 | 8.91 |
| Margin: | -1.86 | 4.47 | 6.33 |
| Total Points: | 70.00 | 58.51 | 11.49 |