| 9/3/2016 | Oklahoma | 23 | at | Houston (9-4) | 33 | at AAC | ||
| 9/10/2016 | UL Monroe (4-8) | 17 | at | Oklahoma | 59 | SBC | ||
| 9/17/2016 | Ohio State (11-2) | 45 | at | Oklahoma | 24 | B10 | ||
| 10/1/2016 | Oklahoma | 52 | at | TCU (6-7,4-5) | 46 | |||
| 10/8/2016 | Texas (5-7,3-6) | 40 | vs | Oklahoma | 45 | Dallas TX | ||
| 10/15/2016 | Kansas State (9-4,6-3) | 17 | at | Oklahoma | 38 | |||
| 10/22/2016 | Oklahoma | 66 | at | Texas Tech (5-7,3-6) | 59 | |||
| 10/29/2016 | Kansas (2-10,1-8) | 3 | at | Oklahoma | 56 | |||
| 11/3/2016 | Oklahoma | 34 | at | Iowa State (3-9,2-7) | 24 | |||
| 11/12/2016 | Baylor (7-6,3-6) | 24 | at | Oklahoma | 45 | |||
| 11/19/2016 | Oklahoma | 56 | at | West Virginia (10-3,7-2) | 28 | |||
| 12/3/2016 | Oklahoma State (10-3,7-2) | 20 | at | Oklahoma | 38 | |||
| 1/2/2017 | Auburn (8-5) | 19 | vs | Oklahoma | 35 | Sugar Bowl (New Orleans LA) | SEC |
| vs Oklahoma | vs Other Opponents | Oklahoma compared to OOs | |
| Record: | 2-11 | 87-64 | |
| Points Scored: | 28.85 | 32.78 | 3.93 |
| Points Allowed: | 43.92 | 26.74 | 17.18 |
| Margin: | -15.07 | 6.04 | 21.11 |
| Total Points: | 72.77 | 59.52 | 13.25 |