| 8/27/2016 | Charleston Southern (7-4) | 17 | at | North Dakota State | 24 | BigS | ||
| 9/10/2016 | Eastern Washington (12-2) | 44 | at | North Dakota State | 50 | OT | BSky | |
| 9/17/2016 | North Dakota State | 23 | at | Iowa (8-5) | 21 | at B10 | ||
| 10/1/2016 | Illinois State (6-6,4-4) | 10 | at | North Dakota State | 31 | |||
| 10/8/2016 | North Dakota State | 27 | at | Missouri State (4-7,2-6) | 3 | |||
| 10/15/2016 | South Dakota State (9-4,7-2) | 19 | at | North Dakota State | 17 | |||
| 10/22/2016 | North Dakota State | 21 | at | Western Illinois (6-5,3-5) | 13 | |||
| 10/29/2016 | North Dakota State | 24 | at | Northern Iowa (5-6,4-4) | 20 | |||
| 11/5/2016 | Youngstown State (12-4,6-2) | 3 | at | North Dakota State | 24 | |||
| 11/12/2016 | Indiana State (4-7,2-6) | 17 | at | North Dakota State | 41 | |||
| 11/19/2016 | North Dakota State | 28 | at | South Dakota (4-7,3-5) | 21 | |||
| 12/3/2016 | San Diego (10-2) | 7 | at | North Dakota State | 45 | 1AA Playoffs | Pio | |
| 12/10/2016 | South Dakota State (9-4,7-2) | 10 | at | North Dakota State | 36 | 1AA Quarterfinals | ||
| 12/16/2016 | James Madison (14-1) | 27 | at | North Dakota State | 17 | 1AA Semifinal | CAAF |
| vs North Dakota State | vs Other Opponents | North Dakota State compared to OOs | |
| Record: | 2-12 | 107-51 | |
| Points Scored: | 16.57 | 33.49 | 16.92 |
| Points Allowed: | 29.14 | 25.11 | 4.03 |
| Margin: | -12.57 | 8.38 | 20.95 |
| Total Points: | 45.71 | 58.60 | -12.89 |