| 9/3/2016 | Valparaiso (4-7) | 13 | at | Illinois State | 50 | Pio | ||
| 9/10/2016 | Illinois State | 9 | at | Northwestern (7-6) | 7 | at B10 | ||
| 9/17/2016 | Eastern Illinois (6-5) | 24 | at | Illinois State | 21 | OVC | ||
| 9/24/2016 | Illinois State | 31 | at | Indiana State (4-7,2-6) | 34 | |||
| 10/1/2016 | Illinois State | 10 | at | North Dakota State (12-2,8-1) | 31 | |||
| 10/8/2016 | Youngstown State (12-4,6-2) | 20 | at | Illinois State | 6 | |||
| 10/15/2016 | Southern Illinois (4-7,2-6) | 28 | at | Illinois State | 31 | |||
| 10/22/2016 | Illinois State | 24 | at | South Dakota (4-7,3-5) | 27 | |||
| 10/29/2016 | South Dakota State (9-4,7-2) | 21 | at | Illinois State | 38 | |||
| 11/5/2016 | Illinois State | 31 | at | Western Illinois (6-5,3-5) | 26 | |||
| 11/12/2016 | Missouri State (4-7,2-6) | 0 | at | Illinois State | 37 | |||
| 11/26/2016 | Illinois State | 24 | at | Central Arkansas (10-3) | 31 | at SLC |
| vs Illinois State | vs Other Opponents | Illinois State compared to OOs | |
| Record: | 6-6 | 76-58 | |
| Points Scored: | 21.83 | 28.75 | 6.92 |
| Points Allowed: | 26.00 | 27.28 | -1.28 |
| Margin: | -4.17 | 1.47 | 5.64 |
| Total Points: | 47.83 | 56.03 | -8.20 |