| 9/3/2016 | Western Michigan | 22 | at | Northwestern (7-6) | 21 | at B10 | ||
| 9/10/2016 | North Carolina Central (9-3) | 21 | at | Western Michigan | 70 | MEAC (1AA) | ||
| 9/17/2016 | Western Michigan | 34 | at | Illinois (3-9) | 10 | at B10 | ||
| 9/24/2016 | Georgia Southern (5-7) | 31 | at | Western Michigan | 49 | SBC | ||
| 10/1/2016 | Western Michigan | 49 | at | Central Michigan (6-7,3-5) | 10 | |||
| 10/8/2016 | Northern Illinois (5-7,5-3) | 30 | at | Western Michigan | 45 | |||
| 10/15/2016 | Western Michigan | 41 | at | Akron (5-7,3-5) | 0 | |||
| 10/22/2016 | Eastern Michigan (7-6,4-4) | 31 | at | Western Michigan | 45 | |||
| 11/1/2016 | Western Michigan | 52 | at | Ball State (4-8,1-7) | 20 | |||
| 11/8/2016 | Western Michigan | 37 | at | Kent State (3-9,2-6) | 21 | |||
| 11/19/2016 | Buffalo (2-10,1-7) | 0 | at | Western Michigan | 38 | |||
| 11/25/2016 | Toledo (9-4,6-2) | 35 | at | Western Michigan | 55 | |||
| 12/2/2016 | Western Michigan | 29 | vs | Ohio (8-6,6-3) | 23 | |||
| 1/2/2017 | Western Michigan | 16 | vs | Wisconsin (11-3) | 24 | Cotton Bowl (Dallas TX) | vs B10 |
| vs Western Michigan | vs Other Opponents | Western Michigan compared to OOs | |
| Record: | 1-13 | 83-79 | |
| Points Scored: | 19.79 | 27.24 | 7.45 |
| Points Allowed: | 41.57 | 25.89 | 15.68 |
| Margin: | -21.78 | 1.35 | 23.13 |
| Total Points: | 61.36 | 53.13 | 8.23 |