| 9/3/2016 | Miami-Ohio | 21 | at | Iowa (8-5) | 45 | at B10 | ||
| 9/10/2016 | Eastern Illinois (6-5) | 21 | at | Miami-Ohio | 17 | OVC (1AA) | ||
| 9/17/2016 | Western Kentucky (11-3) | 31 | at | Miami-Ohio | 24 | CUSA | ||
| 9/24/2016 | Miami-Ohio | 20 | at | Cincinnati (4-8) | 27 | at AAC | ||
| 10/1/2016 | Ohio (8-6,6-3) | 17 | at | Miami-Ohio | 7 | |||
| 10/8/2016 | Miami-Ohio | 13 | at | Akron (5-7,3-5) | 35 | |||
| 10/15/2016 | Kent State (3-9,2-6) | 14 | at | Miami-Ohio | 18 | |||
| 10/22/2016 | Miami-Ohio | 40 | at | Bowling Green (4-8,3-5) | 26 | |||
| 10/29/2016 | Miami-Ohio | 28 | at | Eastern Michigan (7-6,4-4) | 15 | |||
| 11/4/2016 | Central Michigan (6-7,3-5) | 17 | at | Miami-Ohio | 37 | |||
| 11/12/2016 | Miami-Ohio | 35 | at | Buffalo (2-10,1-7) | 24 | |||
| 11/22/2016 | Ball State (4-8,1-7) | 20 | at | Miami-Ohio | 21 | |||
| 12/26/2016 | Miami-Ohio | 16 | vs | Mississippi State (6-7) | 17 | St. Petersburg Bowl | vs SEC |
| vs Miami-Ohio | vs Other Opponents | Miami-Ohio compared to OOs | |
| Record: | 7-6 | 67-83 | |
| Points Scored: | 23.77 | 27.09 | 3.32 |
| Points Allowed: | 22.85 | 29.29 | -6.44 |
| Margin: | 0.92 | -2.20 | -3.12 |
| Total Points: | 46.62 | 56.38 | -9.76 |