9/1/2022 | Monmouth NJ | 21 | at | New Hampshire | 31 | | | |
| Rhode Island | 35 | at | Stony Brook | 14 | | | |
9/2/2022 | William & Mary | 41 | at | UNC-Charlotte | 24 | | | @ CUSA (1A) |
| Lehigh | 17 | at | Villanova | 45 | | | Pat |
9/3/2022 | Albany NY | 10 | at | Baylor | 69 | | | @ B12 (1A) |
| Towson | 14 | at | Bucknell | 13 | OT | | @ Pat |
| Howard | 28 | at | Hampton | 31 | | | MEAC |
| Delaware | 14 | at | Navy | 7 | | | @ AAC (1A) |
| Maine | 0 | at | New Mexico | 41 | | | @ MW (1A) |
| Elon | 31 | at | Vanderbilt | 42 | | | @ SEC (1A) |
| Richmond | 17 | at | Virginia | 34 | | | @ ACC (1A) |
9/10/2022 | New Hampshire | 28 | at | Albany NY | 23 | | | |
| Rhode Island | 35 | at | Bryant | 21 | | | @ BigS |
| Delaware State | 9 | at | Delaware | 35 | | | MEAC |
| Tuskegee | 10 | at | Hampton | 42 | | | SIAC (D2) |
| Villanova | 38 | at | LIU | 21 | | | @ NE |
| Colgate | 21 | at | Maine | 18 | | | Pat |
| Fordham | 52 | at | Monmouth NJ | 49 | | | Pat |
| St Francis PA | 21 | at | Richmond | 31 | | | NE |
| Morgan State | 21 | at | Towson | 29 | | | MEAC |
| Campbell | 21 | at | William & Mary | 37 | | | BigS |
| Elon | 26 | at | Wofford | 0 | | | @ SoCon |
9/17/2022 | Villanova | 10 | at | Army | 49 | | | @ Ind (1A) |
| Maine | 17 | at | Boston College | 38 | | | @ ACC (1A) |
| Gardner-Webb | 24 | at | Elon | 30 | | | BigS |
| Albany NY | 45 | at | Fordham | 48 | | | @ Pat |
| William & Mary | 34 | at | Lafayette | 7 | | | @ Pat |
| Richmond | 30 | at | Lehigh | 6 | | | @ Pat |
| Stony Brook | 3 | at | Massachusetts | 20 | | | @ Ind (1A) |
| Georgetown | 6 | at | Monmouth NJ | 45 | | | Pat |
| North Carolina Central | 45 | at | New Hampshire | 27 | | | MEAC |
| Hampton | 17 | at | Norfolk State | 7 | | | @ MEAC |
| Delaware | 42 | at | Rhode Island | 21 | | | |
| Towson | 7 | at | West Virginia | 65 | | | @ B12 (1A) |
9/24/2022 | Central Conn | 26 | at | Albany NY | 45 | | | NE |
| Hampton | 3 | at | Delaware | 35 | | | |
| Rhode Island | 24 | at | Pittsburgh | 45 | | | @ ACC (1A) |
| Stony Brook | 7 | at | Richmond | 51 | | | |
| New Hampshire | 37 | at | Towson | 14 | | | |
| Monmouth NJ | 49 | at | Villanova | 42 | | | |
| Elon | 35 | at | William & Mary | 31 | | | |
10/1/2022 | Towson | 10 | at | Delaware | 24 | | | |
| Richmond | 27 | at | Elon | 30 | 2OT | | |
| Monmouth NJ | 35 | at | Lehigh | 7 | | | @ Pat |
| Villanova | 45 | at | Maine | 20 | | | |
| Brown | 10 | at | Rhode Island | 38 | | | Ivy |
| William & Mary | 27 | at | Stony Brook | 10 | | | |
| New Hampshire | 7 | at | Western Michigan | 44 | | | @ MAC (1A) |
10/8/2022 | Towson | 10 | at | Elon | 27 | | | |
| Maine | 31 | at | Hampton | 24 | | | |
| Albany NY | 31 | at | Monmouth NJ | 38 | | | |
| Stony Brook | 14 | at | New Hampshire | 24 | | | |
| Delaware | 21 | at | William & Mary | 27 | | | |
10/15/2022 | Hampton | 38 | at | Albany NY | 37 | OT | | |
| New Hampshire | 14 | at | Dartmouth | 0 | | | @ Ivy |
| Stony Brook | 14 | at | Fordham | 45 | | | @ Pat |
| Monmouth NJ | 28 | at | Maine | 38 | | | |
| Elon | 10 | at | Rhode Island | 17 | | | |
| Villanova | 10 | at | Richmond | 20 | | | |
10/22/2022 | Morgan State | 7 | at | Delaware | 38 | | | MEAC |
| Richmond | 41 | at | Hampton | 10 | | | |
| Rhode Island | 48 | at | Monmouth NJ | 46 | 7OT | | |
| Elon | 22 | at | New Hampshire | 40 | | | |
| Maine | 27 | at | Stony Brook | 28 | | | |
| William & Mary | 44 | at | Towson | 24 | | | |
| Albany NY | 29 | at | Villanova | 31 | | | |
10/29/2022 | Stony Brook | 14 | at | Albany NY | 59 | | | |
| Delaware | 7 | at | Elon | 27 | | | |
| Richmond | 31 | at | Maine | 21 | | | |
| Towson | 52 | at | Monmouth NJ | 48 | | | |
| Hampton | 10 | at | Villanova | 24 | | | |
| Rhode Island | 30 | at | William & Mary | 31 | | | |
11/5/2022 | Monmouth NJ | 17 | at | Delaware | 49 | | | |
| Albany NY | 3 | at | Elon | 27 | | | |
| William & Mary | 20 | at | Hampton | 14 | | | |
| Maine | 22 | at | Rhode Island | 26 | | | |
| New Hampshire | 34 | at | Richmond | 40 | | | |
| Morgan State | 22 | at | Stony Brook | 24 | | | MEAC |
| Villanova | 3 | at | Towson | 27 | | | |
11/12/2022 | Maine | 21 | at | Albany NY | 23 | | | |
| Richmond | 21 | at | Delaware | 13 | | | |
| Elon | 38 | at | Hampton | 24 | | | |
| Rhode Island | 28 | at | New Hampshire | 31 | | | |
| Towson | 21 | at | Stony Brook | 17 | | | |
| Villanova | 12 | at | William & Mary | 45 | | | |
11/19/2022 | New Hampshire | 42 | at | Maine | 41 | OT | | |
| Stony Brook | 21 | at | Monmouth NJ | 24 | | | |
| Albany NY | 21 | at | Rhode Island | 35 | | | |
| William & Mary | 37 | at | Richmond | 26 | | | |
| Hampton | 7 | at | Towson | 27 | | | |
| Delaware | 26 | at | Villanova | 29 | | | |
11/26/2022 | St Francis PA | 17 | at | Delaware | 56 | | FCS Championship - Round 1 | NE |
| Elon | 6 | at | Furman | 31 | | FCS Championship - Round 1 | @ SoCon |
| Fordham | 42 | at | New Hampshire | 52 | | FCS Championship - Round 1 | Pat |
| Davidson | 0 | at | Richmond | 41 | | FCS Championship - Round 1 | Pio |
12/3/2022 | New Hampshire | 19 | at | Holy Cross | 35 | | FCS Playoffs Round 2 | @ Pat |
| Richmond | 31 | at | Sacramento State | 38 | | FCS Playoffs Round 2 | @ BSky |
| Delaware | 6 | at | South Dakota State | 42 | | FCS Playoffs Round 2 | @ MVC |
| Gardner-Webb | 14 | at | William & Mary | 54 | | FCS Playoffs Round 2 | BigS |
12/9/2022 | William & Mary | 7 | at | Montana State | 55 | | FCS Quarterful | @ BSky |