| 9/3/2022 | Colgate | 10 | at | Stanford (3-9) | 41 | at P12 | ||
| 9/10/2022 | Colgate | 21 | at | Maine (2-9) | 18 | at CAAF | ||
| 9/17/2022 | Colgate | 14 | at | Pennsylvania (8-2) | 25 | at Ivy | ||
| 9/24/2022 | Holy Cross (12-1,6-0) | 35 | at | Colgate | 10 | |||
| 10/1/2022 | Cornell (5-5) | 34 | at | Colgate | 31 | Ivy | ||
| 10/15/2022 | Colgate | 17 | at | Army (6-6) | 42 | at Ind | ||
| 10/22/2022 | Georgetown (2-9,1-5) | 24 | at | Colgate | 34 | |||
| 10/29/2022 | Colgate | 13 | at | Bucknell (3-8,2-4) | 7 | |||
| 11/5/2022 | Lafayette (4-7,3-3) | 21 | at | Colgate | 16 | |||
| 11/12/2022 | Colgate | 33 | at | Lehigh (2-9,2-4) | 36 | |||
| 11/19/2022 | Colgate | 38 | at | Fordham (9-3,5-1) | 52 |
| vs Colgate | vs Other Opponents | Colgate compared to OOs | |
| Record: | 8-3 | 48-65 | |
| Points Scored: | 30.45 | 24.78 | -5.67 |
| Points Allowed: | 21.55 | 28.65 | -7.10 |
| Margin: | 8.90 | -3.87 | -12.77 |
| Total Points: | 52.00 | 53.43 | -1.43 |