| 9/4/2022 | Fort Valley State (8-2,7-2) | 21 | vs | Tuskegee | 6 | Montgomery AL | ||
| 9/10/2022 | Tuskegee | 10 | at | Hampton (4-7) | 42 | at CAAF | ||
| 9/17/2022 | Tuskegee | 13 | at | West Alabama (5-6) | 10 | at GSC | ||
| 9/24/2022 | Allen (1-8,0-7) | 27 | at | Tuskegee | 35 | |||
| 10/1/2022 | Tuskegee | 45 | at | Clark Atlanta (3-7,3-6) | 43 | |||
| 10/8/2022 | Tuskegee | 31 | vs | Morehouse (1-9,1-6) | 14 | Birmingham AL | ||
| 10/15/2022 | Central State (3-7,2-5) | 34 | at | Tuskegee | 49 | |||
| 10/22/2022 | Tuskegee | 35 | at | Lane (5-5,4-4) | 31 | |||
| 10/29/2022 | Tuskegee | 28 | at | Kentucky State (4-6,4-4) | 7 | |||
| 11/5/2022 | Miles (1-9,1-6) | 23 | at | Tuskegee | 26 | 2OT | ||
| 11/12/2022 | Tuskegee | 21 | at | Benedict (11-1,10-0) | 58 |
| vs Tuskegee | vs Other Opponents | Tuskegee compared to OOs | |
| Record: | 3-8 | 43-59 | |
| Points Scored: | 28.18 | 23.44 | -4.74 |
| Points Allowed: | 27.18 | 27.16 | 0.02 |
| Margin: | 1.00 | -3.72 | -4.72 |
| Total Points: | 55.36 | 50.60 | 4.76 |