| 9/1/2021 | UAB | 31 | vs | Jacksonville State | 0 | Montgomery AL | vs CUSA (1A) | |
| 9/2/2021 | North American U | 3 | at | Lamar | 47 | None (Unk?) | ||
| Sam Houston | 42 | at | Northern Arizona | 16 | @ BSky | |||
| 9/4/2021 | Central Arkansas | 21 | at | Arkansas State | 40 | @ SBC (1A) | ||
| Sacramento State | 19 | at | Dixie State | 7 | BSky | |||
| Abilene Christian | 9 | at | SMU | 56 | @ AAC (1A) | |||
| Tarleton State | 10 | at | Stephen F. Austin | 20 | ||||
| Eastern Kentucky | 31 | at | Western Carolina | 28 | @ SoCon | |||
| 9/11/2021 | Louisiana College | 7 | at | Abilene Christian | 62 | Soon (NAIA) | ||
| Weber State | 41 | at | Dixie State | 3 | BSky | |||
| Jacksonville State | 20 | at | Florida State | 17 | @ ACC (1A) | |||
| Eastern Kentucky | 3 | at | Louisville | 30 | @ ACC (1A) | |||
| Central Arkansas | 34 | at | Missouri State | 43 | @ MVC | |||
| SE Missouri State | 14 | at | Sam Houston | 52 | OVC | |||
| Fort Lewis | 7 | at | Tarleton State | 54 | RMAC (D2) | |||
| Stephen F. Austin | 22 | at | Texas Tech | 28 | @ B12 (1A) | |||
| Lamar | 0 | at | Texas-San Antonio | 54 | @ CUSA (1A) | |||
| 9/18/2021 | Texas-Permian Basin | 9 | at | Abilene Christian | 34 | LSC (D2) | ||
| Ark Pine Bluff | 23 | at | Central Arkansas | 45 | SWAC | |||
| Indiana State | 23 | at | Eastern Kentucky | 21 | MVC | |||
| North Alabama | 24 | at | Jacksonville State | 27 | BigS | |||
| Lamar | 17 | at | Northern Colorado | 10 | OT | @ BSky | ||
| Mississippi Valley State | 13 | at | Stephen F. Austin | 58 | SWAC | |||
| Southern Utah | 40 | vs | Tarleton State | 35 | Arlington TX | vs BSky | ||
| Dixie State | 27 | at | UC Davis | 60 | @ BSky | |||
| 9/25/2021 | Sam Houston | 45 | at | Central Arkansas | 35 | |||
| Austin Peay | 27 | at | Eastern Kentucky | 35 | OVC | |||
| Tennessee-Martin | 34 | at | Jacksonville State | 31 | OVC | |||
| Abilene Christian | 56 | at | Lamar | 0 | ||||
| Lincoln CA | 13 | at | Stephen F. Austin | 61 | None (Unk?) | |||
| New Mexico Highlands | 21 | at | Tarleton State | 40 | RMAC (D2) | |||
| 10/2/2021 | Central Arkansas | 42 | at | Abilene Christian | 21 | |||
| Tarleton State | 3 | at | Eastern Kentucky | 20 | ||||
| Jacksonville State | 6 | at | Kennesaw St | 31 | @ BigS | |||
| Dixie State | 7 | at | South Dakota State | 55 | @ MVC | |||
| Sam Houston | 21 | vs | Stephen F. Austin | 20 | Houston TX | |||
| 10/9/2021 | Abilene Christian | 15 | at | Eastern Kentucky | 30 | |||
| Stephen F. Austin | 24 | at | Jacksonville State | 28 | ||||
| Dixie State | 14 | at | Montana | 31 | @ BSky | |||
| Lamar | 7 | at | Sam Houston | 41 | ||||
| 10/16/2021 | Lamar | 17 | at | Abilene Christian | 24 | |||
| Eastern Kentucky | 38 | at | Central Arkansas | 35 | ||||
| Tarleton State | 41 | at | Dixie State | 20 | ||||
| 10/23/2021 | Stephen F. Austin | 37 | at | Dixie State | 20 | |||
| Central Arkansas | 49 | at | Lamar | 38 | ||||
| Jacksonville State | 7 | at | Sam Houston | 42 | ||||
| Midwestern State | 14 | at | Tarleton State | 17 | LSC (D2) | |||
| 10/30/2021 | Dixie State | 10 | at | Delaware | 17 | @ CAAF | ||
| Lamar | 10 | at | Eastern Kentucky | 42 | ||||
| Central Arkansas | 38 | at | Jacksonville State | 14 | ||||
| Abilene Christian | 27 | at | Stephen F. Austin | 41 | ||||
| Sam Houston | 45 | at | Tarleton State | 27 | ||||
| 11/6/2021 | Texas Wesleyan | 3 | at | Central Arkansas | 63 | Soon (NAIA) | ||
| Abilene Christian | 25 | at | Jacksonville State | 40 | ||||
| Dixie State | 10 | at | Sam Houston | 59 | ||||
| Eastern Kentucky | 17 | at | Stephen F. Austin | 31 | ||||
| Lamar | 21 | at | Tarleton State | 42 | ||||
| 11/13/2021 | Tarleton State | 3 | at | Abilene Christian | 29 | |||
| Stephen F. Austin | 27 | at | Central Arkansas | 14 | ||||
| Fort Lewis | 21 | at | Dixie State | 62 | RMAC (D2) | |||
| Jacksonville State | 38 | at | Lamar | 7 | ||||
| Eastern Kentucky | 28 | at | Sam Houston | 42 | ||||
| 11/20/2021 | Sam Houston | 35 | at | Abilene Christian | 9 | |||
| Missouri State | 55 | at | Dixie State | 24 | MVC | |||
| Jacksonville State | 31 | at | Eastern Kentucky | 39 | 2OT | |||
| Stephen F. Austin | 42 | at | Lamar | 6 | ||||
| Central Arkansas | 3 | at | Tarleton State | 24 | ||||
| 11/27/2021 | Stephen F. Austin | 28 | at | Incarnate Word | 35 | OT | @ SLC | |
| 12/4/2021 | Incarnate Word | 42 | at | Sam Houston | 49 | SLC | ||
| 12/11/2021 | Montana State | 42 | at | Sam Houston | 19 | FCS quarterfinals | BSky |