| 9/2/2021 | Sam Houston (11-1) | 42 | at | Northern Arizona | 16 | WAC | ||
| 9/11/2021 | Northern Arizona | 7 | at | South Dakota (7-5) | 34 | at MVC | ||
| 9/18/2021 | Northern Arizona | 21 | at | Arizona (1-11) | 19 | at P12 | ||
| 9/25/2021 | Northern Arizona | 10 | at | Northern Colorado (3-8,2-6) | 17 | |||
| 10/2/2021 | Idaho State (1-10,1-7) | 17 | at | Northern Arizona | 48 | |||
| 10/16/2021 | Southern Utah (1-10,0-8) | 35 | at | Northern Arizona | 59 | |||
| 10/23/2021 | Northern Arizona | 0 | at | Sacramento State (9-3,8-0) | 44 | |||
| 10/30/2021 | Northern Arizona | 38 | at | Idaho (4-7,3-5) | 31 | |||
| 11/6/2021 | UC Davis (8-4,5-3) | 40 | at | Northern Arizona | 24 | |||
| 11/13/2021 | Montana (10-3,7-2) | 30 | at | Northern Arizona | 3 | |||
| 11/20/2021 | Northern Arizona | 45 | at | Cal Poly (2-9,1-7) | 21 |
| vs Northern Arizona | vs Other Opponents | Northern Arizona compared to OOs | |
| Record: | 6-5 | 51-66 | |
| Points Scored: | 30.00 | 23.68 | -6.32 |
| Points Allowed: | 24.64 | 27.68 | -3.04 |
| Margin: | 5.36 | -4.00 | -9.36 |
| Total Points: | 54.64 | 51.36 | 3.28 |