| 9/4/2021 | Arizona Christian (8-2,7-2) | 28 | at | Texas Wesleyan | 35 | |||
| 9/11/2021 | Texas Wesleyan | 49 | at | Panhandle State (4-7,3-6) | 20 | |||
| 9/18/2021 | Texas Wesleyan | 31 | at | Ottawa AZ (8-2,8-1) | 45 | |||
| 10/2/2021 | Wayland Baptist (2-8,2-7) | 7 | at | Texas Wesleyan | 63 | |||
| 10/9/2021 | Texas Wesleyan | 38 | at | Southwestern Assemblies of God (9-3,6-3) | 33 | |||
| 10/16/2021 | Texas Wesleyan | 31 | at | Langston (7-3,6-3) | 42 | |||
| 10/23/2021 | Louisiana College (4-7,4-5) | 39 | at | Texas Wesleyan | 56 | |||
| 10/30/2021 | Texas College (0-11,0-9) | 18 | at | Texas Wesleyan | 69 | |||
| 11/6/2021 | Texas Wesleyan | 3 | at | Central Arkansas (5-6) | 63 | at WAC | ||
| 11/13/2021 | Texas Wesleyan | 48 | vs | Lyon (2-8,2-7) | 13 |
| vs Texas Wesleyan | vs Other Opponents | Texas Wesleyan compared to OOs | |
| Record: | 3-7 | 46-50 | |
| Points Scored: | 30.80 | 31.43 | 0.63 |
| Points Allowed: | 42.30 | 32.55 | 9.75 |
| Margin: | -11.50 | -1.12 | 10.38 |
| Total Points: | 73.10 | 63.98 | 9.12 |