| 9/2/2021 | Incarnate Word | 41 | at | Youngstown State (3-7) | 44 | OT | at MVC | |
| 9/11/2021 | Prairie View (7-5) | 9 | at | Incarnate Word | 40 | SWAC | ||
| 9/18/2021 | Incarnate Word | 42 | at | Texas State (4-8) | 34 | at SBC | ||
| 9/25/2021 | McNeese State (4-7,3-5) | 0 | at | Incarnate Word | 31 | |||
| 10/2/2021 | Incarnate Word | 38 | at | Northwestern State (3-8,3-5) | 27 | |||
| 10/16/2021 | Nicholls State (6-5,5-3) | 21 | at | Incarnate Word | 38 | |||
| 10/23/2021 | Incarnate Word | 20 | at | McNeese State (4-7,3-5) | 28 | |||
| 10/30/2021 | Houston Baptist (0-11,0-8) | 21 | at | Incarnate Word | 49 | |||
| 11/6/2021 | Southeastern Louisiana (9-4,6-2) | 52 | at | Incarnate Word | 55 | |||
| 11/13/2021 | Incarnate Word | 27 | at | Nicholls State (6-5,5-3) | 23 | |||
| 11/20/2021 | Incarnate Word | 55 | at | Houston Baptist (0-11,0-8) | 14 | |||
| 11/27/2021 | Stephen F. Austin (8-4) | 28 | at | Incarnate Word | 35 | OT | WAC | |
| 12/4/2021 | Incarnate Word | 42 | at | Sam Houston (11-1) | 49 | at WAC |
| vs Incarnate Word | vs Other Opponents | Incarnate Word compared to OOs | |
| Record: | 3-10 | 61-68 | |
| Points Scored: | 26.92 | 29.75 | 2.83 |
| Points Allowed: | 39.46 | 30.60 | 8.86 |
| Margin: | -12.54 | -0.85 | 11.69 |
| Total Points: | 66.38 | 60.35 | 6.03 |