| 9/3/2021 | South Dakota State | 42 | at | Colorado State (3-9) | 23 | at MW | ||
| 9/11/2021 | Lindenwood (9-3) | 7 | at | South Dakota State | 52 | MAIAA (D2) | ||
| 9/25/2021 | South Dakota State | 44 | at | Indiana State (5-6,3-5) | 0 | |||
| 10/2/2021 | Dixie State (1-10) | 7 | at | South Dakota State | 55 | WAC | ||
| 10/9/2021 | Southern Illinois (8-5,6-4) | 42 | at | South Dakota State | 41 | OT | ||
| 10/16/2021 | South Dakota State | 41 | at | Western Illinois (2-9,2-6) | 17 | |||
| 10/23/2021 | Northern Iowa (6-6,4-4) | 26 | at | South Dakota State | 17 | |||
| 10/30/2021 | South Dakota State | 47 | at | Youngstown State (3-7,2-6) | 16 | |||
| 11/6/2021 | North Dakota State (14-1,8-1) | 19 | at | South Dakota State | 27 | |||
| 11/13/2021 | South Dakota State | 20 | at | South Dakota (7-5,5-4) | 23 | |||
| 11/20/2021 | North Dakota (5-6,3-5) | 21 | at | South Dakota State | 24 | |||
| 11/27/2021 | UC Davis (8-4) | 24 | at | South Dakota State | 56 | BSky | ||
| 12/4/2021 | South Dakota State | 24 | at | Sacramento State (9-3) | 19 | at BSky | ||
| 12/11/2021 | South Dakota State | 35 | at | Villanova (10-3) | 21 | FCS quarterfinals | at CAAF | |
| 12/18/2021 | South Dakota State | 17 | at | Montana State (12-3) | 31 | FCS semifinal | at BSky |
| vs South Dakota State | vs Other Opponents | South Dakota State compared to OOs | |
| Record: | 4-11 | 98-69 | |
| Points Scored: | 19.73 | 27.59 | 7.86 |
| Points Allowed: | 36.13 | 22.69 | 13.44 |
| Margin: | -16.40 | 4.90 | 21.30 |
| Total Points: | 55.86 | 50.28 | 5.58 |