| 9/3/2021 | Northern Colorado | 7 | at | Colorado (4-8) | 35 | at P12 | ||
| 9/11/2021 | Northern Colorado | 45 | at | Houston Baptist (0-11) | 13 | at SLC | ||
| 9/18/2021 | Lamar (2-9) | 17 | at | Northern Colorado | 10 | OT | WAC | |
| 9/25/2021 | Northern Arizona (5-6,4-4) | 10 | at | Northern Colorado | 17 | |||
| 10/2/2021 | Northern Colorado | 7 | at | Montana State (12-3,7-1) | 40 | |||
| 10/9/2021 | Eastern Washington (10-3,6-3) | 63 | at | Northern Colorado | 17 | |||
| 10/16/2021 | Northern Colorado | 3 | at | UC Davis (8-4,5-3) | 32 | |||
| 10/23/2021 | Northern Colorado | 17 | at | Southern Utah (1-10,0-8) | 9 | |||
| 10/30/2021 | Sacramento State (9-3,8-0) | 27 | at | Northern Colorado | 24 | |||
| 11/6/2021 | Montana (10-3,7-2) | 35 | at | Northern Colorado | 0 | |||
| 11/20/2021 | Northern Colorado | 17 | at | Weber State (6-5,5-3) | 48 |
| vs Northern Colorado | vs Other Opponents | Northern Colorado compared to OOs | |
| Record: | 8-3 | 59-62 | |
| Points Scored: | 29.91 | 26.21 | -3.70 |
| Points Allowed: | 14.91 | 27.23 | -12.32 |
| Margin: | 15.00 | -1.02 | -16.02 |
| Total Points: | 44.82 | 53.44 | -8.62 |