| 9/2/2021 | Tennessee-Martin | 21 | at | Western Kentucky (9-5) | 59 | at CUSA | ||
| 9/11/2021 | Samford (4-7) | 27 | at | Tennessee-Martin | 33 | SoCon | ||
| 9/18/2021 | Tennessee-Martin | 35 | at | Northwestern State (3-8) | 10 | at SLC | ||
| 9/25/2021 | Tennessee-Martin | 34 | at | Jacksonville State (5-6) | 31 | at WAC | ||
| 10/9/2021 | Murray State (6-5,5-3) | 24 | at | Tennessee-Martin | 48 | |||
| 10/16/2021 | Tennessee-Martin | 28 | at | Eastern Illinois (1-10,1-6) | 17 | |||
| 10/23/2021 | SE Missouri State (4-7,4-4) | 30 | at | Tennessee-Martin | 38 | |||
| 10/30/2021 | Austin Peay (6-5,4-3) | 16 | at | Tennessee-Martin | 17 | |||
| 11/6/2021 | Tennessee State (5-6,4-3) | 20 | at | Tennessee-Martin | 41 | |||
| 11/13/2021 | Tennessee-Martin | 42 | at | Tennessee Tech (3-8,1-5) | 3 | |||
| 11/20/2021 | Tennessee-Martin | 14 | at | SE Missouri State (4-7,4-4) | 31 | |||
| 11/27/2021 | Tennessee-Martin | 32 | at | Missouri State (8-4) | 31 | at MVC | ||
| 12/4/2021 | Tennessee-Martin | 7 | at | Montana State (12-3) | 26 | at BSky |
| vs Tennessee-Martin | vs Other Opponents | Tennessee-Martin compared to OOs | |
| Record: | 3-10 | 66-70 | |
| Points Scored: | 25.00 | 27.76 | 2.76 |
| Points Allowed: | 30.00 | 28.49 | 1.51 |
| Margin: | -5.00 | -0.73 | 4.27 |
| Total Points: | 55.00 | 56.25 | -1.25 |