| 9/4/2021 | Montana State | 16 | at | Wyoming (7-6) | 19 | at MW | ||
| 9/11/2021 | Drake (2-8) | 7 | at | Montana State | 45 | Pio | ||
| 9/18/2021 | San Diego (7-4) | 10 | at | Montana State | 52 | Pio | ||
| 9/25/2021 | Montana State | 30 | at | Portland State (5-6,4-4) | 17 | |||
| 10/2/2021 | Northern Colorado (3-8,2-6) | 7 | at | Montana State | 40 | |||
| 10/9/2021 | Cal Poly (2-9,1-7) | 7 | at | Montana State | 45 | |||
| 10/15/2021 | Montana State | 13 | at | Weber State (6-5,5-3) | 7 | |||
| 10/23/2021 | Idaho State (1-10,1-7) | 9 | at | Montana State | 27 | |||
| 11/6/2021 | Montana State | 23 | at | Eastern Washington (10-3,6-3) | 20 | |||
| 11/13/2021 | Idaho (4-7,3-5) | 13 | at | Montana State | 20 | |||
| 11/20/2021 | Montana State | 10 | at | Montana (10-3,7-2) | 29 | |||
| 12/4/2021 | Tennessee-Martin (10-3) | 7 | at | Montana State | 26 | OVC | ||
| 12/11/2021 | Montana State | 42 | at | Sam Houston (11-1) | 19 | FCS quarterfinals | at WAC | |
| 12/18/2021 | South Dakota State (11-4) | 17 | at | Montana State | 31 | FCS semifinal | MVC | |
| 1/8/2022 | Montana State | 10 | vs | North Dakota State (14-1) | 38 | FCS Championship - Frisco TX | vs MVC |
| vs Montana State | vs Other Opponents | Montana State compared to OOs | |
| Record: | 3-12 | 100-66 | |
| Points Scored: | 15.07 | 29.11 | 14.04 |
| Points Allowed: | 28.67 | 24.23 | 4.44 |
| Margin: | -13.60 | 4.88 | 18.48 |
| Total Points: | 43.74 | 53.34 | -9.60 |