| 9/4/2021 | Southeastern Louisiana (9-4) | 49 | at | North Alabama | 28 | SLC | ||
| 9/11/2021 | Chattanooga (6-5) | 20 | at | North Alabama | 0 | SoCon | ||
| 9/18/2021 | North Alabama | 24 | at | Jacksonville State (5-6) | 27 | at WAC | ||
| 9/25/2021 | North Alabama | 14 | at | Nicholls State (6-5) | 31 | at SLC | ||
| 10/2/2021 | Campbell (3-8,2-5) | 48 | at | North Alabama | 31 | |||
| 10/9/2021 | North Alabama | 34 | at | North Carolina A&T (5-6,3-4) | 38 | |||
| 10/16/2021 | Robert Morris (4-6,3-5) | 31 | at | North Alabama | 42 | |||
| 10/23/2021 | Charleston Southern (4-6,3-4) | 22 | at | North Alabama | 45 | |||
| 11/6/2021 | North Alabama | 33 | at | Monmouth NJ (7-4,6-1) | 45 | |||
| 11/13/2021 | Kennesaw St (11-2,7-0) | 28 | at | North Alabama | 24 | |||
| 11/20/2021 | North Alabama | 35 | at | Hampton (5-6,3-4) | 27 |
| vs North Alabama | vs Other Opponents | North Alabama compared to OOs | |
| Record: | 8-3 | 57-55 | |
| Points Scored: | 33.27 | 28.48 | -4.79 |
| Points Allowed: | 28.18 | 27.35 | 0.83 |
| Margin: | 5.09 | 1.13 | -3.96 |
| Total Points: | 61.45 | 55.83 | 5.62 |