| 9/4/2021 | Central Arkansas (5-6) | 21 | at | Arkansas State | 40 | WAC (1AA) | ||
| 9/11/2021 | Memphis (6-6) | 55 | at | Arkansas State | 50 | AAC | ||
| 9/18/2021 | Arkansas State | 3 | at | Washington (4-8) | 52 | at P12 | ||
| 9/25/2021 | Arkansas State | 34 | at | Tulsa (7-6) | 41 | at AAC | ||
| 10/2/2021 | Arkansas State | 33 | at | Georgia Southern (3-9,2-6) | 59 | |||
| 10/7/2021 | Coastal Carolina (11-2,6-2) | 52 | at | Arkansas State | 20 | |||
| 10/21/2021 | UL Lafayette (13-1,9-0) | 28 | at | Arkansas State | 27 | |||
| 10/30/2021 | Arkansas State | 13 | at | South Alabama (5-7,2-6) | 31 | |||
| 11/6/2021 | Appalachian State (10-4,7-2) | 48 | at | Arkansas State | 14 | |||
| 11/13/2021 | Arkansas State | 27 | at | UL Monroe (4-8,2-6) | 24 | |||
| 11/20/2021 | Arkansas State | 20 | at | Georgia State (8-5,6-2) | 28 | |||
| 11/27/2021 | Texas State (4-8,3-5) | 24 | at | Arkansas State | 22 |
| vs Arkansas State | vs Other Opponents | Arkansas State compared to OOs | |
| Record: | 10-2 | 70-68 | |
| Points Scored: | 38.58 | 27.28 | -11.30 |
| Points Allowed: | 25.25 | 26.64 | -1.39 |
| Margin: | 13.33 | 0.64 | -12.69 |
| Total Points: | 63.83 | 53.92 | 9.91 |