| 9/4/2021 | Missouri State | 16 | at | Oklahoma State (12-2) | 23 | at B12 | ||
| 9/11/2021 | Central Arkansas (5-6) | 34 | at | Missouri State | 43 | WAC | ||
| 9/25/2021 | South Dakota (7-5,5-4) | 23 | at | Missouri State | 31 | |||
| 10/2/2021 | Missouri State | 41 | at | Illinois State (4-7,2-6) | 20 | |||
| 10/9/2021 | Missouri State | 33 | at | Youngstown State (3-7,2-6) | 41 | |||
| 10/16/2021 | Indiana State (5-6,3-5) | 7 | at | Missouri State | 37 | |||
| 10/23/2021 | Missouri State | 20 | at | North Dakota State (14-1,8-1) | 27 | |||
| 10/30/2021 | North Dakota (5-6,3-5) | 28 | at | Missouri State | 32 | |||
| 11/6/2021 | Missouri State | 38 | at | Southern Illinois (8-5,6-4) | 28 | |||
| 11/13/2021 | Northern Iowa (6-6,4-4) | 27 | at | Missouri State | 34 | |||
| 11/20/2021 | Missouri State | 55 | at | Dixie State (1-10) | 24 | at WAC | ||
| 11/27/2021 | Tennessee-Martin (10-3) | 32 | at | Missouri State | 31 | OVC |
| vs Missouri State | vs Other Opponents | Missouri State compared to OOs | |
| Record: | 4-8 | 76-56 | |
| Points Scored: | 26.17 | 26.69 | 0.52 |
| Points Allowed: | 34.25 | 23.02 | 11.23 |
| Margin: | -8.08 | 3.67 | 11.75 |
| Total Points: | 60.42 | 49.71 | 10.71 |