| 9/4/2021 | Montana | 13 | at | Washington (4-8) | 7 | at P12 | ||
| 9/11/2021 | Western Illinois (2-9) | 7 | at | Montana | 42 | MVC | ||
| 9/25/2021 | Cal Poly (2-9,1-7) | 7 | at | Montana | 39 | |||
| 10/2/2021 | Montana | 28 | at | Eastern Washington (10-3,6-3) | 34 | |||
| 10/9/2021 | Dixie State (1-10) | 14 | at | Montana | 31 | WAC | ||
| 10/16/2021 | Sacramento State (9-3,8-0) | 28 | at | Montana | 21 | |||
| 10/23/2021 | Montana | 34 | at | Idaho (4-7,3-5) | 14 | |||
| 10/30/2021 | Southern Utah (1-10,0-8) | 19 | at | Montana | 20 | |||
| 11/6/2021 | Montana | 35 | at | Northern Colorado (3-8,2-6) | 0 | |||
| 11/13/2021 | Montana | 30 | at | Northern Arizona (5-6,4-4) | 3 | |||
| 11/20/2021 | Montana State (12-3,7-1) | 10 | at | Montana | 29 | |||
| 12/3/2021 | Eastern Washington (10-3,6-3) | 41 | at | Montana | 57 | |||
| 12/10/2021 | Montana | 6 | at | James Madison (12-2) | 28 | FCS quarterfinals | at CAAF |
| vs Montana | vs Other Opponents | Montana compared to OOs | |
| Record: | 3-10 | 71-70 | |
| Points Scored: | 16.31 | 28.96 | 12.65 |
| Points Allowed: | 29.62 | 28.47 | 1.15 |
| Margin: | -13.31 | 0.49 | 13.80 |
| Total Points: | 45.93 | 57.43 | -11.50 |