| 9/2/2016 | Northwestern State | 7 | at | Baylor | 55 | SLC (1AA) | ||
| Kansas State | 13 | at | Stanford | 26 | @ P12 | |||
| 9/3/2016 | Oklahoma | 23 | at | Houston | 33 | @ AAC | ||
| Northern Iowa | 25 | at | Iowa State | 20 | MVC (1AA) | |||
| Rhode Island | 6 | at | Kansas | 55 | CAAF (1AA) | |||
| Southeastern Louisiana | 7 | at | Oklahoma State | 61 | SLC (1AA) | |||
| South Dakota State | 41 | at | TCU | 59 | MVC (1AA) | |||
| Stephen F. Austin | 17 | at | Texas Tech | 69 | SLC (1AA) | |||
| Missouri | 11 | at | West Virginia | 26 | SEC | |||
| 9/4/2016 | Notre Dame | 47 | at | Texas | 50 | 2OT | ND | |
| 9/10/2016 | Texas Tech | 55 | at | Arizona State | 68 | @ P12 | ||
| SMU | 13 | at | Baylor | 40 | AAC | |||
| Iowa State | 3 | at | Iowa | 42 | @ B10 | |||
| Ohio | 37 | at | Kansas | 21 | MAC | |||
| UL Monroe | 17 | at | Oklahoma | 59 | SBC | |||
| Central Michigan | 30 | at | Oklahoma State | 27 | MAC | |||
| Arkansas | 41 | at | TCU | 38 | 2OT | SEC | ||
| UTEP | 7 | at | Texas | 41 | CUSA | |||
| Youngstown State | 21 | at | West Virginia | 38 | MVC (1AA) | |||
| 9/16/2016 | Baylor | 38 | at | Rice | 10 | @ CUSA | ||
| 9/17/2016 | Texas | 43 | at | California | 50 | @ P12 | ||
| Florida Atlantic | 7 | at | Kansas State | 63 | CUSA | |||
| Kansas | 7 | at | Memphis | 43 | @ AAC | |||
| Ohio State | 45 | at | Oklahoma | 24 | B10 | |||
| Pittsburgh | 38 | at | Oklahoma State | 45 | ACC | |||
| Iowa State | 20 | at | TCU | 41 | ||||
| Louisiana Tech | 45 | at | Texas Tech | 59 | CUSA | |||
| 9/23/2016 | TCU | 33 | at | SMU | 3 | @ AAC | ||
| 9/24/2016 | Oklahoma State | 24 | at | Baylor | 35 | |||
| San Jose State | 10 | at | Iowa State | 44 | MW | |||
| Missouri State | 0 | at | Kansas State | 35 | MVC (1AA) | |||
| BYU | 32 | vs | West Virginia | 35 | Landover MD | vs Ind | ||
| 9/29/2016 | Kansas | 19 | at | Texas Tech | 55 | |||
| 10/1/2016 | Baylor | 45 | at | Iowa State | 42 | |||
| Texas | 31 | at | Oklahoma State | 49 | ||||
| Oklahoma | 52 | at | TCU | 46 | ||||
| Kansas State | 16 | at | West Virginia | 17 | ||||
| 10/8/2016 | TCU | 24 | at | Kansas | 23 | |||
| Texas Tech | 38 | at | Kansas State | 44 | ||||
| Texas | 40 | vs | Oklahoma | 45 | Dallas TX | |||
| Iowa State | 31 | at | Oklahoma State | 38 | ||||
| 10/15/2016 | Kansas | 7 | at | Baylor | 49 | |||
| Kansas State | 17 | at | Oklahoma | 38 | ||||
| Iowa State | 6 | at | Texas | 27 | ||||
| West Virginia | 48 | at | Texas Tech | 17 | ||||
| 10/22/2016 | Oklahoma State | 44 | at | Kansas | 20 | |||
| Texas | 21 | at | Kansas State | 24 | ||||
| Oklahoma | 66 | at | Texas Tech | 59 | ||||
| TCU | 10 | at | West Virginia | 34 | ||||
| 10/29/2016 | Kansas State | 31 | at | Iowa State | 26 | |||
| Kansas | 3 | at | Oklahoma | 56 | ||||
| West Virginia | 20 | at | Oklahoma State | 37 | ||||
| Texas Tech | 27 | at | TCU | 24 | ||||
| Baylor | 34 | at | Texas | 35 | ||||
| 11/3/2016 | Oklahoma | 34 | at | Iowa State | 24 | |||
| 11/5/2016 | TCU | 62 | at | Baylor | 22 | |||
| Oklahoma State | 43 | at | Kansas State | 37 | ||||
| Texas | 45 | at | Texas Tech | 37 | ||||
| Kansas | 21 | at | West Virginia | 48 | ||||
| 11/12/2016 | Iowa State | 31 | at | Kansas | 24 | |||
| Baylor | 24 | at | Oklahoma | 45 | ||||
| Texas Tech | 44 | at | Oklahoma State | 45 | ||||
| West Virginia | 24 | at | Texas | 20 | ||||
| 11/19/2016 | Kansas State | 42 | at | Baylor | 21 | |||
| Texas Tech | 10 | at | Iowa State | 66 | ||||
| Texas | 21 | at | Kansas | 24 | OT | |||
| Oklahoma State | 31 | at | TCU | 6 | ||||
| Oklahoma | 56 | at | West Virginia | 28 | ||||
| 11/25/2016 | TCU | 31 | at | Texas | 9 | |||
| Baylor | 35 | vs | Texas Tech | 54 | Arlington TX | |||
| 11/26/2016 | West Virginia | 49 | at | Iowa State | 19 | |||
| Kansas | 19 | at | Kansas State | 34 | ||||
| 12/3/2016 | Oklahoma State | 20 | at | Oklahoma | 38 | |||
| Kansas State | 30 | at | TCU | 6 | ||||
| Baylor | 21 | at | West Virginia | 24 | ||||
| 12/27/2016 | Boise State | 12 | vs | Baylor | 31 | Cactus Bowl (Phoenix AZ) | vs MW | |
| 12/28/2016 | Texas A&M | 28 | vs | Kansas State | 33 | Texas Bowl (Houston TX) | vs SEC | |
| West Virginia | 14 | vs | Miami-Florida | 31 | Russell Athletic Bowl (Orlando FL) | vs ACC | ||
| 12/29/2016 | Oklahoma State | 38 | vs | Colorado | 8 | Alamo Bowl (San Antonio TX) | vs P12 | |
| 12/30/2016 | Georgia | 31 | vs | TCU | 23 | Liberty Bowl (Memphis TN) | vs SEC | |
| 1/2/2017 | Auburn | 19 | vs | Oklahoma | 35 | Sugar Bowl (New Orleans LA) | vs SEC |