| 9/3/2016 | Miami-Ohio (6-7) | 21 | at | Iowa | 45 | MAC | ||
| 9/10/2016 | Iowa State (3-9) | 3 | at | Iowa | 42 | B12 | ||
| 9/17/2016 | North Dakota State (12-2) | 23 | at | Iowa | 21 | MVC (1AA) | ||
| 9/24/2016 | Iowa | 14 | at | Rutgers (2-10,0-9) | 7 | |||
| 10/1/2016 | Northwestern (7-6,5-4) | 38 | at | Iowa | 31 | |||
| 10/8/2016 | Iowa | 14 | at | Minnesota (9-4,5-4) | 7 | |||
| 10/15/2016 | Iowa | 49 | at | Purdue (3-9,1-8) | 35 | |||
| 10/22/2016 | Wisconsin (11-3,7-3) | 17 | at | Iowa | 9 | |||
| 11/5/2016 | Iowa | 14 | at | Penn State (11-3,9-1) | 41 | |||
| 11/12/2016 | Michigan (10-3,7-2) | 13 | at | Iowa | 14 | |||
| 11/19/2016 | Iowa | 28 | at | Illinois (3-9,2-7) | 0 | |||
| 11/25/2016 | Nebraska (9-4,6-3) | 10 | at | Iowa | 40 | |||
| 1/2/2017 | Florida (9-4) | 30 | vs | Iowa | 3 | Outback Bowl (Tampa FL) | SEC |
| vs Iowa | vs Other Opponents | Iowa compared to OOs | |
| Record: | 5-8 | 90-65 | |
| Points Scored: | 18.85 | 27.95 | 9.10 |
| Points Allowed: | 24.92 | 24.17 | 0.75 |
| Margin: | -6.07 | 3.78 | 9.85 |
| Total Points: | 43.77 | 52.12 | -8.35 |