| 9/1/2016 | Duquesne (8-3) | 10 | at | Youngstown State | 45 | NE | ||
| 9/10/2016 | Youngstown State | 21 | at | West Virginia (10-3) | 38 | at B12 | ||
| 9/17/2016 | Robert Morris (2-9) | 6 | at | Youngstown State | 38 | NE | ||
| 10/1/2016 | South Dakota (4-7,3-5) | 20 | at | Youngstown State | 30 | |||
| 10/8/2016 | Youngstown State | 20 | at | Illinois State (6-6,4-4) | 6 | |||
| 10/15/2016 | Northern Iowa (5-6,4-4) | 10 | at | Youngstown State | 14 | |||
| 10/22/2016 | Youngstown State | 10 | at | South Dakota State (9-4,7-2) | 24 | |||
| 10/29/2016 | Indiana State (4-7,2-6) | 10 | at | Youngstown State | 13 | |||
| 11/5/2016 | Youngstown State | 3 | at | North Dakota State (12-2,8-1) | 24 | |||
| 11/12/2016 | Southern Illinois (4-7,2-6) | 14 | at | Youngstown State | 21 | |||
| 11/19/2016 | Youngstown State | 65 | at | Missouri State (4-7,2-6) | 20 | |||
| 11/26/2016 | Samford (7-5) | 24 | at | Youngstown State | 38 | SoCon | ||
| 12/3/2016 | Youngstown State | 40 | at | Jacksonville State (10-2) | 24 | 1AA Playoffs | at OVC | |
| 12/10/2016 | Wofford (10-4) | 23 | at | Youngstown State | 30 | 2OT | 1AA Quarterfinals | SoCon |
| 12/17/2016 | Youngstown State | 40 | at | Eastern Washington (12-2) | 38 | 1AA Semifinal | at BSky | |
| 1/7/2017 | Youngstown State | 14 | vs | James Madison (14-1) | 28 | 1AA Championship (Frisco TX) | vs CAAF |
| vs Youngstown State | vs Other Opponents | Youngstown State compared to OOs | |
| Record: | 4-12 | 117-63 | |
| Points Scored: | 19.94 | 31.57 | 11.63 |
| Points Allowed: | 27.63 | 24.68 | 2.95 |
| Margin: | -7.69 | 6.89 | 14.58 |
| Total Points: | 47.57 | 56.25 | -8.68 |