| 9/3/2016 | Missouri | 11 | at | West Virginia (10-3) | 26 | at B12 | ||
| 9/10/2016 | Eastern Michigan (7-6) | 21 | at | Missouri | 61 | MAC | ||
| 9/17/2016 | Georgia (8-5,4-4) | 28 | at | Missouri | 27 | |||
| 9/24/2016 | Delaware State (0-11) | 0 | at | Missouri | 79 | MEAC (1AA) | ||
| 10/1/2016 | Missouri | 7 | at | LSU (8-4,5-3) | 42 | |||
| 10/15/2016 | Missouri | 14 | at | Florida (9-4,6-3) | 40 | |||
| 10/22/2016 | Middle Tenn State (8-5) | 51 | at | Missouri | 45 | CUSA | ||
| 10/29/2016 | Kentucky (7-6,4-4) | 35 | at | Missouri | 21 | |||
| 11/5/2016 | Missouri | 21 | at | South Carolina (6-7,3-5) | 31 | |||
| 11/12/2016 | Vanderbilt (6-7,3-5) | 17 | at | Missouri | 26 | |||
| 11/19/2016 | Missouri | 37 | at | Tennessee (9-4,4-4) | 63 | |||
| 11/25/2016 | Arkansas (7-6,3-5) | 24 | at | Missouri | 28 |
| vs Missouri | vs Other Opponents | Missouri compared to OOs | |
| Record: | 8-4 | 77-64 | |
| Points Scored: | 31.50 | 27.56 | -3.94 |
| Points Allowed: | 31.42 | 26.85 | 4.57 |
| Margin: | 0.08 | 0.71 | 0.63 |
| Total Points: | 62.92 | 54.41 | 8.51 |