| 9/3/2016 | Louisiana Tech | 20 | at | Arkansas (7-6) | 21 | at SEC | ||
| 9/10/2016 | South Carolina State (5-6) | 24 | at | Louisiana Tech | 53 | MEAC (1AA) | ||
| 9/17/2016 | Louisiana Tech | 45 | at | Texas Tech (5-7) | 59 | at B12 | ||
| 9/24/2016 | Louisiana Tech | 34 | at | Middle Tenn State (8-5,5-3) | 38 | |||
| 10/1/2016 | UTEP (4-8,2-6) | 7 | at | Louisiana Tech | 28 | |||
| 10/6/2016 | Western Kentucky (11-3,8-1) | 52 | at | Louisiana Tech | 55 | |||
| 10/15/2016 | Louisiana Tech | 56 | vs | Massachusetts (2-10) | 28 | Foxboro MA | vs MAC | |
| 10/22/2016 | Louisiana Tech | 44 | at | Florida Intl (4-8,4-4) | 24 | |||
| 10/29/2016 | Rice (3-9,2-6) | 16 | at | Louisiana Tech | 61 | |||
| 11/5/2016 | Louisiana Tech | 45 | at | North Texas (5-8,3-5) | 24 | |||
| 11/12/2016 | Texas-San Antonio (6-7,5-3) | 35 | at | Louisiana Tech | 63 | |||
| 11/25/2016 | Louisiana Tech | 24 | at | Southern Miss (7-6,4-4) | 39 | |||
| 12/3/2016 | Louisiana Tech | 44 | at | Western Kentucky (11-3,8-1) | 58 | |||
| 12/23/2016 | Louisiana Tech | 48 | vs | Navy (9-5) | 45 | Armed Forces Bowl (Fort Worth TX) | vs AAC |
| vs Louisiana Tech | vs Other Opponents | Louisiana Tech compared to OOs | |
| Record: | 5-9 | 81-81 | |
| Points Scored: | 33.57 | 32.81 | -0.76 |
| Points Allowed: | 44.29 | 31.04 | 13.25 |
| Margin: | -10.72 | 1.77 | 12.49 |
| Total Points: | 77.86 | 63.85 | 14.01 |