| 9/3/2016 | South Dakota State | 41 | at | TCU (6-7) | 59 | at B12 | ||
| 9/10/2016 | Drake (7-4) | 28 | at | South Dakota State | 56 | Pio | ||
| 9/17/2016 | Cal Poly (7-5) | 38 | at | South Dakota State | 31 | BSky | ||
| 10/1/2016 | Western Illinois (6-5,3-5) | 14 | at | South Dakota State | 52 | |||
| 10/8/2016 | South Dakota State | 45 | at | Southern Illinois (4-7,2-6) | 39 | |||
| 10/15/2016 | South Dakota State | 19 | at | North Dakota State (12-2,8-1) | 17 | |||
| 10/22/2016 | Youngstown State (12-4,6-2) | 10 | at | South Dakota State | 24 | |||
| 10/29/2016 | South Dakota State | 21 | at | Illinois State (6-6,4-4) | 38 | |||
| 11/5/2016 | Missouri State (4-7,2-6) | 24 | at | South Dakota State | 49 | |||
| 11/12/2016 | South Dakota (4-7,3-5) | 21 | at | South Dakota State | 28 | |||
| 11/19/2016 | South Dakota State | 45 | at | Northern Iowa (5-6,4-4) | 24 | |||
| 12/3/2016 | Villanova (9-4) | 7 | at | South Dakota State | 10 | 1AA Playoffs | CAAF | |
| 12/10/2016 | South Dakota State | 10 | at | North Dakota State (12-2,8-1) | 36 | 1AA Quarterfinals |
| vs South Dakota State | vs Other Opponents | South Dakota State compared to OOs | |
| Record: | 4-9 | 89-56 | |
| Points Scored: | 27.31 | 29.14 | 1.83 |
| Points Allowed: | 33.15 | 24.66 | 8.49 |
| Margin: | -5.84 | 4.48 | 10.32 |
| Total Points: | 60.46 | 53.80 | 6.66 |