| 9/3/2016 | SMU | 34 | at | North Texas (5-8) | 21 | at CUSA | ||
| 9/10/2016 | SMU | 13 | at | Baylor (7-6) | 40 | at B12 | ||
| 9/17/2016 | Liberty (6-5) | 14 | at | SMU | 29 | BigS (1AA) | ||
| 9/23/2016 | TCU (6-7) | 33 | at | SMU | 3 | B12 | ||
| 10/1/2016 | SMU | 20 | at | Temple (10-4,8-1) | 45 | |||
| 10/7/2016 | SMU | 40 | at | Tulsa (10-3,6-2) | 43 | OT | ||
| 10/22/2016 | Houston (9-4,5-3) | 16 | at | SMU | 38 | |||
| 10/29/2016 | SMU | 35 | at | Tulane (4-8,1-7) | 31 | |||
| 11/5/2016 | Memphis (8-5,5-3) | 51 | at | SMU | 7 | |||
| 11/12/2016 | SMU | 55 | at | East Carolina (3-9,1-7) | 31 | |||
| 11/19/2016 | South Florida (11-2,7-1) | 35 | at | SMU | 27 | |||
| 11/26/2016 | Navy (9-5,7-2) | 75 | at | SMU | 31 |
| vs SMU | vs Other Opponents | SMU compared to OOs | |
| Record: | 7-5 | 81-61 | |
| Points Scored: | 36.25 | 33.32 | -2.93 |
| Points Allowed: | 27.67 | 28.56 | -0.89 |
| Margin: | 8.58 | 4.76 | -3.82 |
| Total Points: | 63.92 | 61.88 | 2.04 |