| 8/28/2021 | Lincoln CA | 9 | at | Arizona Christian | 33 | @ Soon (NAIA) | ||
| North American U | 42 | at | Louisiana College | 41 | @ Soon (NAIA) | |||
| Fort Lauderdale | at | Southeastern FL | 1 | Forfeit | @ MSC (NAIA) | |||
| Arkansas Baptist | 14 | at | Tabor | 29 | @ KCAC (NAIA) | |||
| 9/2/2021 | North American U | 3 | at | Lamar | 47 | @ WAC (1AA) | ||
| 9/4/2021 | Virginia U-Lynchburg | 0 | at | Virginia-Wise | 54 | @ SAC (D2) | ||
| 9/9/2021 | Virginia U-Lynchburg | 14 | at | Mars Hill | 50 | @ SAC (D2) | ||
| 9/11/2021 | Apprentice | 34 | at | Brevard | 27 | OT | @ USASC (D3) | |
| Arkansas Baptist | 0 | at | Missouri S&T | 71 | @ GLV (D2) | |||
| Fort Lauderdale | 3 | at | Presbyterian | 68 | @ Pio (1AA) | |||
| Lincoln CA | 29 | at | Whitworth | 31 | @ NWC (D3) | |||
| 9/16/2021 | North American U | 0 | at | West Alabama | 80 | @ GSC (D2) | ||
| 9/18/2021 | Birmingham-Southern | 55 | at | Arkansas Baptist | 6 | SAA (D3) | ||
| Apprentice | 7 | at | Emory & Henry | 63 | @ D2Ind (D2) | |||
| Fort Lauderdale | 0 | at | Mississippi College | 63 | @ GSC (D2) | |||
| Virginia U-Lynchburg | 7 | at | Virginia Union | 49 | @ CIAA (D2) | |||
| Lincoln CA | 34 | at | Willamette | 9 | @ NWC (D3) | |||
| 9/25/2021 | Virginia U-Lynchburg | 7 | at | Duquesne | 56 | @ NE (1AA) | ||
| Apprentice | 28 | at | Ferrum | 30 | @ ODC (D3) | |||
| Arkansas Baptist | 6 | at | Langston | 85 | @ Soon (NAIA) | |||
| Lincoln CA | 13 | at | Stephen F. Austin | 61 | @ WAC (1AA) | |||
| Fort Lauderdale | at | West Florida | Cancelled | @ GSC (D2) | ||||
| 10/2/2021 | Guilford | at | Apprentice | Canceled | ODC (D3) | |||
| Lincoln CA | 6 | at | Eastern New Mexico | 52 | @ LSC (D2) | |||
| Virginia U-Lynchburg | 13 | at | Erskine | 59 | @ D2Ind (D2) | |||
| Arkansas Baptist | 6 | at | Southwestern Assemblies of God | 50 | @ Soon (NAIA) | |||
| Fort Lauderdale | 6 | at | Texas A&M-Commerce | 72 | @ LSC (D2) | |||
| North American U | 0 | at | Texas Southern | 69 | @ SWAC (1AA) | |||
| 10/9/2021 | Fort Lauderdale | 9 | at | Bluefield St WV | 23 | @ D2Ind (D2) | ||
| Virginia U-Lynchburg | 6 | at | Delaware State | 56 | @ MEAC (1AA) | |||
| North American U | 44 | at | Sul Ross State | 37 | Exhibition | @ ASWC (D3) | ||
| Lincoln CA | 0 | at | Texas-Permian Basin | 75 | @ LSC (D2) | |||
| Apprentice | 13 | at | Washington and Lee | 42 | @ ODC (D3) | |||
| 10/16/2021 | Apprentice | 7 | at | Bridgewater VA | 27 | @ ODC (D3) | ||
| St Thomas FL | 58 | at | Fort Lauderdale | 0 | MSC (NAIA) | |||
| Virginia U-Lynchburg | 14 | at | Norfolk State | 42 | @ MEAC (1AA) | |||
| Lincoln CA | 21 | at | Texas A&M-Kingsville | 51 | @ LSC (D2) | |||
| 10/23/2021 | Arkansas Baptist | 18 | at | Panhandle State | 52 | @ Soon (NAIA) | ||
| Apprentice | 7 | at | Randolph-Macon | 49 | @ ODC (D3) | |||
| Virginia U-Lynchburg | 13 | at | Tennessee Tech | 56 | @ OVC (1AA) | |||
| 10/28/2021 | Fort Lauderdale | 8 | at | Virginia U-Lynchburg | 70 | |||
| 10/30/2021 | Hampden-Sydney | 38 | at | Apprentice | 21 | ODC (D3) | ||
| Lincoln CA | 0 | at | Central Washington | 92 | @ GNWAC (D2) | |||
| 11/6/2021 | Arkansas Baptist | 6 | at | Kansas Wesleyan | 81 | @ KCAC (NAIA) | ||
| Eastern New Mexico | 70 | at | North American U | 21 | LSC (D2) | |||
| Apprentice | 16 | at | Shenandoah | 35 | @ ODC (D3) | |||
| Lincoln CA | 6 | at | Western Colorado | 72 | @ RMAC (D2) | |||
| 11/13/2021 | Virginia U-Lynchburg | 34 | at | Fort Lauderdale | 30 | |||
| Lincoln CA | 16 | at | Western Oregon | 55 | @ GNWAC (D2) | |||
| 11/20/2021 | Virginia U-Lynchburg | 6 | at | Howard | 56 | Suspended in 1st half | @ MEAC (1AA) |