| 9/4/2021 | Erskine | 27 | at | Catawba (5-4) | 37 | at SAC | ||
| 9/11/2021 | Barton (6-5,2-0) | 38 | at | Erskine | 25 | |||
| 9/18/2021 | Erskine | 19 | at | Chowan (7-3) | 49 | at CIAA | ||
| 9/25/2021 | North Greenville (5-6) | 38 | at | Erskine | 7 | GSC | ||
| 10/2/2021 | Virginia U-Lynchburg (2-9) | 13 | at | Erskine | 59 | None (Unk?) | ||
| 10/9/2021 | Erskine | 6 | at | Savannah State (8-2) | 39 | at SIAC | ||
| 10/16/2021 | Bluefield St WV (3-3,0-2) | 19 | at | Erskine | 24 | |||
| 10/23/2021 | Allen (3-5) | 40 | at | Erskine | 47 | SIAC | ||
| 10/30/2021 | Newberry (10-3) | 48 | at | Erskine | 10 | SAC | ||
| 11/6/2021 | Erskine | 7 | at | Shorter (3-8) | 38 | at GSC | ||
| 11/13/2021 | Kentucky State (7-4) | 41 | at | Erskine | 17 | SIAC |
| vs Erskine | vs Other Opponents | Erskine compared to OOs | |
| Record: | 8-3 | 51-49 | |
| Points Scored: | 36.36 | 25.40 | -10.96 |
| Points Allowed: | 22.55 | 27.70 | -5.15 |
| Margin: | 13.81 | -2.30 | -16.11 |
| Total Points: | 58.91 | 53.10 | 5.81 |