| 9/4/2021 | Langston | 10 | at | Panhandle State (4-7,3-6) | 7 | |||
| 9/11/2021 | Texas College (0-11,0-9) | 6 | at | Langston | 44 | |||
| 9/18/2021 | Langston | 50 | at | Wayland Baptist (2-8,2-7) | 0 | |||
| 9/25/2021 | Arkansas Baptist (0-7) | 6 | at | Langston | 85 | None (Unk?) | ||
| 10/2/2021 | Langston | 30 | at | Lyon (2-8,2-7) | 0 | |||
| 10/16/2021 | Texas Wesleyan (7-3,7-2) | 31 | at | Langston | 42 | |||
| 10/23/2021 | Langston | 44 | at | Ottawa AZ (8-2,8-1) | 41 | |||
| 10/30/2021 | Langston | 24 | at | Louisiana College (4-7,4-5) | 31 | |||
| 11/6/2021 | Arizona Christian (8-2,7-2) | 40 | at | Langston | 37 | OT | ||
| 11/13/2021 | Southwestern Assemblies of God (9-3,6-3) | 41 | at | Langston | 24 |
| vs Langston | vs Other Opponents | Langston compared to OOs | |
| Record: | 3-7 | 41-51 | |
| Points Scored: | 20.30 | 30.78 | 10.48 |
| Points Allowed: | 39.00 | 36.63 | 2.37 |
| Margin: | -18.70 | -5.85 | 12.85 |
| Total Points: | 59.30 | 67.41 | -8.11 |