| 8/28/2021 | North American U (2-4) | 42 | at | Louisiana College | 41 | None (Unk?) | ||
| 9/4/2021 | Southwestern Assemblies of God (9-3,6-3) | 20 | at | Louisiana College | 13 | |||
| 9/11/2021 | Louisiana College | 7 | at | Abilene Christian (5-6) | 62 | at WAC | ||
| 9/18/2021 | Louisiana College | 22 | at | Arizona Christian (8-2,7-2) | 35 | |||
| 9/25/2021 | Ottawa AZ (8-2,8-1) | 49 | at | Louisiana College | 19 | |||
| 10/2/2021 | Panhandle State (4-7,3-6) | 35 | at | Louisiana College | 41 | |||
| 10/16/2021 | Louisiana College | 27 | at | Wayland Baptist (2-8,2-7) | 24 | |||
| 10/23/2021 | Louisiana College | 39 | at | Texas Wesleyan (7-3,7-2) | 56 | |||
| 10/30/2021 | Langston (7-3,6-3) | 24 | at | Louisiana College | 31 | |||
| 11/6/2021 | Louisiana College | 33 | at | Lyon (2-8,2-7) | 35 | |||
| 11/13/2021 | Texas College (0-11,0-9) | 12 | at | Louisiana College | 77 |
| vs Louisiana College | vs Other Opponents | Louisiana College compared to OOs | |
| Record: | 7-4 | 47-53 | |
| Points Scored: | 35.82 | 30.46 | -5.36 |
| Points Allowed: | 31.82 | 34.20 | -2.38 |
| Margin: | 4.00 | -3.74 | -7.74 |
| Total Points: | 67.64 | 64.66 | 2.98 |