| 9/4/2021 | Duquesne | 3 | at | TCU (5-7) | 45 | at B12 | ||
| 9/11/2021 | Duquesne | 28 | at | Ohio (3-9) | 26 | at MAC | ||
| 9/25/2021 | Virginia U-Lynchburg (2-9) | 7 | at | Duquesne | 56 | None (Unk?) | ||
| 10/2/2021 | Duquesne | 37 | at | Merrimack (5-6,2-5) | 14 | |||
| 10/9/2021 | Bryant (7-4,5-2) | 34 | at | Duquesne | 39 | |||
| 10/23/2021 | Duquesne | 13 | at | Sacred Heart (8-4,6-1) | 31 | |||
| 10/30/2021 | St Francis PA (5-6,4-3) | 17 | at | Duquesne | 10 | |||
| 11/6/2021 | Duquesne | 34 | at | LIU (2-8,2-5) | 28 | |||
| 11/13/2021 | Central Conn (4-7,4-3) | 27 | at | Duquesne | 31 | |||
| 11/20/2021 | Duquesne | 44 | at | Wagner (0-11,0-7) | 0 |
| vs Duquesne | vs Other Opponents | Duquesne compared to OOs | |
| Record: | 3-7 | 38-64 | |
| Points Scored: | 22.90 | 21.62 | -1.28 |
| Points Allowed: | 29.50 | 30.39 | -0.89 |
| Margin: | -6.60 | -8.77 | -2.17 |
| Total Points: | 52.40 | 52.01 | 0.39 |