| 9/4/2021 | West Florida | 42 | at | McNeese State (4-7) | 36 | at SLC | ||
| 9/11/2021 | Southwest Baptist (4-7) | 14 | at | West Florida | 63 | GLV | ||
| 9/18/2021 | West Florida | 35 | at | Texas A&M-Commerce (7-4) | 17 | at LSC | ||
| 9/25/2021 | Fort Lauderdale (0-7) | at | West Florida | Cancelled | None (Unk?) | |||
| 10/2/2021 | West Florida | 39 | at | Delta State (5-6,3-5) | 33 | |||
| 10/9/2021 | West Florida | 52 | at | North Greenville (5-6,2-5) | 10 | |||
| 10/16/2021 | West Georgia (9-3,6-3) | 30 | at | West Florida | 26 | |||
| 10/23/2021 | Shorter (3-8,0-7) | 23 | at | West Florida | 45 | |||
| 10/30/2021 | West Florida | 63 | at | Mississippi College (4-6,3-5) | 28 | |||
| 11/6/2021 | West Florida | 47 | at | West Alabama (7-4,4-4) | 7 | |||
| 11/13/2021 | Valdosta State (12-2,7-1) | 42 | at | West Florida | 61 | |||
| 11/20/2021 | Newberry (10-3) | 33 | at | West Florida | 30 | OT | SAC |
| vs West Florida | vs Other Opponents | West Florida compared to OOs | |
| Record: | 2-9 | 68-54 | |
| Points Scored: | 24.82 | 28.92 | 4.10 |
| Points Allowed: | 45.73 | 24.86 | 20.87 |
| Margin: | -20.91 | 4.06 | 24.97 |
| Total Points: | 70.55 | 53.78 | 16.77 |