| 9/4/2021 | Virginia Union | 28 | at | Hampton (5-6) | 42 | at BigS | ||
| 9/11/2021 | Valdosta State (12-2) | 51 | at | Virginia Union | 7 | GSC | ||
| 9/18/2021 | Virginia U-Lynchburg (2-9) | 7 | at | Virginia Union | 49 | None (Unk?) | ||
| 9/25/2021 | Virginia Union | 43 | at | Johnson C Smith (1-7,1-5) | 7 | |||
| 10/2/2021 | Shaw (6-4,5-2) | 27 | at | Virginia Union | 7 | |||
| 10/9/2021 | Lincoln PA (1-9,1-6) | 0 | at | Virginia Union | 32 | |||
| 10/16/2021 | Virginia Union | 38 | at | Chowan (7-3,4-3) | 31 | |||
| 10/23/2021 | Bowie State (12-2,8-0) | 27 | at | Virginia Union | 7 | |||
| 10/30/2021 | Virginia Union | 44 | at | Elizabeth City State (3-7,3-5) | 14 | |||
| 11/6/2021 | Virginia State (3-6,3-4) | 13 | at | Virginia Union | 20 |
| vs Virginia Union | vs Other Opponents | Virginia Union compared to OOs | |
| Record: | 4-6 | 48-49 | |
| Points Scored: | 21.90 | 25.80 | 3.90 |
| Points Allowed: | 27.50 | 27.03 | 0.47 |
| Margin: | -5.60 | -1.23 | 4.37 |
| Total Points: | 49.40 | 52.83 | -3.43 |