| 9/2/2021 | Texas A&M-Commerce | 12 | at | Colorado State-Pueblo (6-5) | 6 | at RMAC | ||
| 9/11/2021 | Midwestern State (7-3,6-1) | 31 | vs | Texas A&M-Commerce | 30 | Arlington TX | ||
| 9/18/2021 | West Florida (9-2) | 35 | at | Texas A&M-Commerce | 17 | GSC | ||
| 9/25/2021 | Texas A&M-Commerce | 35 | at | Texas A&M-Kingsville (5-5,3-4) | 10 | |||
| 10/2/2021 | Fort Lauderdale (0-7) | 6 | at | Texas A&M-Commerce | 72 | None (Unk?) | ||
| 10/9/2021 | Saginaw Valley State (7-4) | 20 | at | Texas A&M-Commerce | 17 | OT | GLIAC | |
| 10/16/2021 | Western New Mexico (1-9,0-7) | 0 | at | Texas A&M-Commerce | 58 | |||
| 10/23/2021 | Texas A&M-Commerce | 15 | at | West Texas A&M (7-4,5-2) | 3 | |||
| 10/30/2021 | Texas-Permian Basin (5-6,3-4) | 0 | at | Texas A&M-Commerce | 41 | |||
| 11/6/2021 | Texas A&M-Commerce | 3 | at | Angelo State (11-3,5-2) | 30 | |||
| 11/13/2021 | Eastern New Mexico (4-7,1-6) | 10 | at | Texas A&M-Commerce | 30 |
| vs Texas A&M-Commerce | vs Other Opponents | Texas A&M-Commerce compared to OOs | |
| Record: | 4-7 | 58-48 | |
| Points Scored: | 13.73 | 30.86 | 17.13 |
| Points Allowed: | 30.00 | 26.57 | 3.43 |
| Margin: | -16.27 | 4.29 | 20.56 |
| Total Points: | 43.73 | 57.43 | -13.70 |