| 9/4/2021 | Tarleton State (6-5,3-4) | 10 | at | Stephen F. Austin | 20 | |||
| 9/11/2021 | Stephen F. Austin | 22 | at | Texas Tech (7-6) | 28 | at B12 | ||
| 9/18/2021 | Mississippi Valley State (4-7) | 13 | at | Stephen F. Austin | 58 | SWAC | ||
| 9/25/2021 | Lincoln CA (1-9) | 13 | at | Stephen F. Austin | 61 | None (Unk?) | ||
| 10/2/2021 | Sam Houston (11-1,8-0) | 21 | vs | Stephen F. Austin | 20 | Houston TX | ||
| 10/9/2021 | Stephen F. Austin | 24 | at | Jacksonville State (5-6,3-3) | 28 | |||
| 10/23/2021 | Stephen F. Austin | 37 | at | Dixie State (1-10,0-3) | 20 | |||
| 10/30/2021 | Abilene Christian (5-6,3-5) | 27 | at | Stephen F. Austin | 41 | |||
| 11/6/2021 | Eastern Kentucky (7-4,5-2) | 17 | at | Stephen F. Austin | 31 | |||
| 11/13/2021 | Stephen F. Austin | 27 | at | Central Arkansas (5-6,3-4) | 14 | |||
| 11/20/2021 | Stephen F. Austin | 42 | at | Lamar (2-9,0-8) | 6 | |||
| 11/27/2021 | Stephen F. Austin | 28 | at | Incarnate Word (10-3) | 35 | OT | at SLC |
| vs Stephen F. Austin | vs Other Opponents | Stephen F. Austin compared to OOs | |
| Record: | 4-8 | 60-64 | |
| Points Scored: | 19.33 | 27.60 | 8.27 |
| Points Allowed: | 34.25 | 29.96 | 4.29 |
| Margin: | -14.92 | -2.36 | 12.56 |
| Total Points: | 53.58 | 57.56 | -3.98 |