| 9/4/2021 | Puget Sound (1-9,1-7) | 35 | at | Willamette | 48 | |||
| 9/18/2021 | Lincoln CA (1-9) | 34 | at | Willamette | 9 | None (Unk?) | ||
| 9/25/2021 | Willamette | 8 | at | Pomona-Pitzer (4-5) | 44 | at SCIAC | ||
| 10/2/2021 | Pacific (6-3,5-2) | 49 | at | Willamette | 19 | |||
| 10/9/2021 | Willamette | 14 | at | George Fox (6-3,6-1) | 44 | |||
| 10/16/2021 | Lewis & Clark (3-6,2-5) | 43 | at | Willamette | 41 | |||
| 10/23/2021 | Willamette | 7 | at | Whitworth (7-3,4-3) | 66 | |||
| 10/30/2021 | Pacific Lutheran (4-5,3-4) | 24 | at | Willamette | 0 | |||
| 11/6/2021 | Linfield (11-1,7-0) | 77 | at | Willamette | 7 | |||
| 11/13/2021 | Willamette | 34 | at | Puget Sound (1-9,1-7) | 62 |
| vs Willamette | vs Other Opponents | Willamette compared to OOs | |
| Record: | 9-1 | 34-51 | |
| Points Scored: | 47.80 | 26.33 | -21.47 |
| Points Allowed: | 18.70 | 33.20 | -14.50 |
| Margin: | 29.10 | -6.87 | -35.97 |
| Total Points: | 66.50 | 59.53 | 6.97 |