| 9/4/2021 | LaGrange (2-8) | 17 | at | Birmingham-Southern | 42 | USASC | ||
| 9/11/2021 | Birmingham-Southern | 48 | at | Huntingdon AL (8-3) | 9 | at USASC | ||
| 9/18/2021 | Birmingham-Southern | 55 | at | Arkansas Baptist (0-7) | 6 | at None | ||
| 10/2/2021 | Sewanee (0-10,0-8) | 0 | at | Birmingham-Southern | 49 | |||
| 10/9/2021 | Birmingham-Southern | 43 | at | Hendrix (3-7,3-5) | 6 | |||
| 10/16/2021 | Birmingham-Southern | 28 | at | Centre (8-2,5-2) | 21 | |||
| 10/23/2021 | Rhodes (3-7,2-5) | 6 | at | Birmingham-Southern | 41 | |||
| 10/30/2021 | Birmingham-Southern | 21 | at | Berry (6-4,4-3) | 3 | |||
| 11/6/2021 | Trinity TX (9-1,7-0) | 28 | at | Birmingham-Southern | 27 | |||
| 11/13/2021 | Birmingham-Southern | 49 | at | Millsaps (2-8,2-5) | 7 | |||
| 11/20/2021 | Huntingdon AL (8-3) | 14 | at | Birmingham-Southern | 24 | USASC | ||
| 11/27/2021 | Birmingham-Southern | 7 | at | Mary Hardin-Baylor (15-0) | 42 | at ASWC |
| vs Birmingham-Southern | vs Other Opponents | Birmingham-Southern compared to OOs | |
| Record: | 2-10 | 62-48 | |
| Points Scored: | 13.25 | 32.19 | 18.94 |
| Points Allowed: | 36.17 | 28.30 | 7.87 |
| Margin: | -22.92 | 3.89 | 26.81 |
| Total Points: | 49.42 | 60.49 | -11.07 |