| 9/4/2021 | Chadron State (6-5,5-4) | 10 | at | Western Colorado | 23 | |||
| 9/11/2021 | Western Colorado | 49 | at | Western New Mexico (1-9) | 14 | at LSC | ||
| 9/18/2021 | Western Colorado | 24 | at | Adams State (1-10,1-8) | 10 | |||
| 9/25/2021 | Fort Lewis (0-11,0-9) | 0 | at | Western Colorado | 42 | |||
| 10/2/2021 | Western Colorado | 14 | at | Colorado Mines (12-2,8-1) | 20 | OT | ||
| 10/9/2021 | New Mexico Highlands (4-6,4-5) | 38 | at | Western Colorado | 45 | |||
| 10/16/2021 | Black Hills State (4-7,2-7) | 28 | at | Western Colorado | 44 | |||
| 10/23/2021 | Western Colorado | 42 | at | South Dakota Tech (6-5,4-5) | 21 | |||
| 10/30/2021 | Colorado Mesa (8-2,7-2) | 9 | at | Western Colorado | 23 | |||
| 11/6/2021 | Lincoln CA (1-9) | 6 | at | Western Colorado | 72 | None (Unk?) | ||
| 11/13/2021 | Colorado State-Pueblo (6-5,6-3) | 7 | at | Western Colorado | 14 | |||
| 11/20/2021 | Nebraska-Kearney (10-3) | 31 | at | Western Colorado | 24 | MAIAA |
| vs Western Colorado | vs Other Opponents | Western Colorado compared to OOs | |
| Record: | 2-10 | 57-64 | |
| Points Scored: | 16.17 | 27.48 | 11.31 |
| Points Allowed: | 34.67 | 30.45 | 4.22 |
| Margin: | -18.50 | -2.97 | 15.53 |
| Total Points: | 50.84 | 57.93 | -7.09 |