| 9/4/2021 | Virginia U-Lynchburg (2-9) | 0 | at | Virginia-Wise | 54 | None (Unk?) | ||
| 9/11/2021 | Virginia-Wise | 14 | at | East Tennessee St (11-2) | 45 | at SoCon | ||
| 9/18/2021 | Virginia-Wise | 9 | at | Mars Hill (8-3,6-2) | 44 | |||
| 9/25/2021 | Carson-Newman (1-9,1-7) | 7 | at | Virginia-Wise | 33 | |||
| 10/2/2021 | Lenoir-Rhyne (8-3,6-2) | 28 | at | Virginia-Wise | 35 | |||
| 10/9/2021 | Newberry (10-3,7-1) | 37 | at | Virginia-Wise | 14 | |||
| 10/16/2021 | Virginia-Wise | 21 | at | Tusculum (5-6,3-5) | 37 | |||
| 10/23/2021 | Wingate (7-3,5-2) | 48 | at | Virginia-Wise | 21 | |||
| 10/30/2021 | Virginia-Wise | 28 | at | Limestone (0-9,0-7) | 24 | |||
| 11/6/2021 | Virginia-Wise | 30 | at | Catawba (5-4,2-4) | 7 | |||
| 11/13/2021 | Barton (6-5) | 36 | at | Virginia-Wise | 24 | D2Ind |
| vs Virginia-Wise | vs Other Opponents | Virginia-Wise compared to OOs | |
| Record: | 6-5 | 57-51 | |
| Points Scored: | 28.45 | 26.58 | -1.87 |
| Points Allowed: | 25.73 | 26.42 | -0.69 |
| Margin: | 2.72 | 0.16 | -2.56 |
| Total Points: | 54.18 | 53.00 | 1.18 |