| 9/4/2021 | Norfolk State | 10 | at | Toledo (7-6) | 49 | at MAC | ||
| 9/11/2021 | Norfolk State | 16 | at | Wake Forest (11-3) | 41 | at ACC | ||
| 9/18/2021 | Elizabeth City State (3-7) | 26 | at | Norfolk State | 63 | CIAA (D2) | ||
| 9/25/2021 | Norfolk State | 28 | at | St Francis PA (5-6) | 16 | at NE | ||
| 10/2/2021 | Norfolk State | 47 | at | Hampton (5-6) | 44 | OT | at BigS | |
| 10/16/2021 | Virginia U-Lynchburg (2-9) | 14 | at | Norfolk State | 42 | None (Unk?) | ||
| 10/23/2021 | Norfolk State | 45 | at | Howard (3-8,1-4) | 31 | |||
| 10/30/2021 | Morgan State (2-9,1-4) | 20 | at | Norfolk State | 31 | |||
| 11/6/2021 | Norfolk State | 36 | at | North Carolina Central (6-5,4-1) | 38 | 2OT | ||
| 11/13/2021 | Norfolk State | 26 | at | Delaware State (5-6,2-3) | 28 | |||
| 11/20/2021 | South Carolina State (7-5,5-0) | 31 | at | Norfolk State | 21 |
| vs Norfolk State | vs Other Opponents | Norfolk State compared to OOs | |
| Record: | 5-6 | 51-64 | |
| Points Scored: | 30.73 | 24.55 | -6.18 |
| Points Allowed: | 33.18 | 28.90 | 4.28 |
| Margin: | -2.45 | -4.35 | -1.90 |
| Total Points: | 63.91 | 53.45 | 10.46 |