| 9/4/2021 | Howard | 14 | at | Richmond (6-5) | 38 | at CAAF | ||
| 9/11/2021 | Howard | 0 | at | Maryland (7-6) | 62 | at B10 | ||
| 9/18/2021 | Hampton (5-6) | 48 | at | Howard | 32 | BigS | ||
| 9/25/2021 | Howard | 16 | at | Robert Morris (4-6) | 22 | at BigS | ||
| 10/2/2021 | Sacred Heart (8-4) | 17 | at | Howard | 22 | NE | ||
| 10/8/2021 | Morgan State (2-9,1-4) | 0 | at | Howard | 27 | |||
| 10/23/2021 | Norfolk State (6-5,2-3) | 45 | at | Howard | 31 | |||
| 10/30/2021 | Howard | 23 | at | Delaware State (5-6,2-3) | 30 | |||
| 11/6/2021 | Howard | 12 | at | South Carolina State (7-5,5-0) | 15 | |||
| 11/13/2021 | North Carolina Central (6-5,4-1) | 45 | at | Howard | 27 | |||
| 11/20/2021 | Virginia U-Lynchburg (2-9) | 6 | at | Howard | 56 | Suspended in 1st half | None (Unk?) |
| vs Howard | vs Other Opponents | Howard compared to OOs | |
| Record: | 8-3 | 50-63 | |
| Points Scored: | 29.82 | 22.91 | -6.91 |
| Points Allowed: | 23.64 | 29.12 | -5.48 |
| Margin: | 6.18 | -6.21 | -12.39 |
| Total Points: | 53.46 | 52.03 | 1.43 |