| 8/26/2010 | Southern Virginia @ Concord | |
| 8/28/2010 | Bowie State @ Seton Hill | |
| 8/28/2010 | Shepherd @ Shippensburg | |
| 8/28/2010 | Charleston WV @ Tusculum | |
| 8/28/2010 | St Paul's @ West Virginia Wesleyan | |
| 9/2/2010 | Fairmont State @ Clarion | |
| 9/2/2010 | West Virginia Tech @ Glenville State | |
| 9/4/2010 | West Virginia State vs Central State | |
| 9/4/2010 | Mars Hill @ Charleston WV | |
| 9/4/2010 | Concord @ Lenoir-Rhyne | |
| 9/4/2010 | New Haven @ Seton Hill | |
| 9/4/2010 | Edinboro @ West Liberty | |
| 9/4/2010 | Urbana @ West Virginia Wesleyan | |
| 9/11/2010 | Notre Dame OH @ Fairmont State | |
| 9/11/2010 | North Alabama @ Glenville State | |
| 9/11/2010 | St Joseph's @ Shepherd | |
| 9/11/2010 | West Liberty @ Southern Connecticut | |
| 9/11/2010 | Seton Hill @ Urbana | |
| 9/11/2010 | West Virginia State @ Virginia State | |
| 9/18/2010 | West Virginia State @ Charleston WV | † |
| 9/18/2010 | Seton Hill @ Glenville State | † |
| 9/18/2010 | Fairmont State @ Shepherd | † |
| 9/18/2010 | Concord @ West Virginia Wesleyan | † |
| 9/25/2010 | Charleston WV @ Concord | † |
| 9/25/2010 | Fairmont State @ Glenville State | † |
| 9/25/2010 | Shepherd @ Seton Hill | † |
| 9/25/2010 | West Virginia Wesleyan @ West Liberty | † |
| 9/25/2010 | Johnson C Smith @ West Virginia State | |
| 9/30/2010 | West Liberty @ Fairmont State | † |
| 10/2/2010 | Shepherd @ Charleston WV | † |
| 10/2/2010 | UNC Pembroke @ Glenville State | |
| 10/2/2010 | Concord @ West Virginia State | † |
| 10/2/2010 | Seton Hill @ West Virginia Wesleyan | † |
| 10/9/2010 | Fairmont State @ Charleston WV | † |
| 10/9/2010 | West Virginia Wesleyan @ Livingstone | |
| 10/9/2010 | West Virginia State @ Seton Hill | † |
| 10/9/2010 | Concord @ Shepherd | † |
| 10/9/2010 | Glenville State @ West Liberty | † |
| 10/16/2010 | Seton Hill @ Charleston WV | † |
| 10/16/2010 | Glenville State @ Concord | † |
| 10/16/2010 | West Virginia Wesleyan @ Shepherd | † |
| 10/16/2010 | Fairmont State @ UNC Pembroke | |
| 10/16/2010 | West Liberty @ West Virginia State | † |
| 10/23/2010 | West Virginia Wesleyan @ Fairmont State | † |
| 10/23/2010 | West Virginia State @ Glenville State | † |
| 10/23/2010 | Concord @ Seton Hill | † |
| 10/23/2010 | Charleston WV @ Urbana | |
| 10/23/2010 | Shepherd @ West Liberty | † |
| 10/30/2010 | Seton Hill @ Fairmont State | † |
| 10/30/2010 | Concord @ UNC Pembroke | |
| 10/30/2010 | Charleston WV @ West Liberty | † |
| 10/30/2010 | Shepherd @ West Virginia State | † |
| 10/30/2010 | Glenville State @ West Virginia Wesleyan | † |
| 11/6/2010 | Fairmont State @ Concord | † |
| 11/6/2010 | Charleston WV @ Glenville State | † |
| 11/6/2010 | West Liberty @ Seton Hill | † |
| 11/6/2010 | West Virginia Wesleyan @ West Virginia State | † |
| 11/13/2010 | West Liberty @ Concord | † |
| 11/13/2010 | West Virginia State @ Fairmont State | † |
| 11/13/2010 | Glenville State @ Shepherd | † |
| 11/13/2010 | Charleston WV @ West Virginia Wesleyan | † |