| 9/4/2010 | West Virginia State Yellow Jackets 14 vs Central State 34 (Dayton OH) | |
| 9/11/2010 | Central State 0 @ Alabama A&M Bulldogs 45 | |
| 9/18/2010 | Kentucky Wesleyan Panthers 38 @ Central State 33 | † |
| 9/25/2010 | Central State 13 @ Dayton Flyers 45 | |
| 10/2/2010 | Notre Dame OH Falcons 16 @ Central State 13 | |
| 10/9/2010 | Kentucky State Thorobreds 41 @ Central State 24 | |
| 10/16/2010 | St Augustine's Falcons 21 @ Central State 14 | |
| 10/23/2010 | Central State 0 @ Southwest Baptist Bearcats 52 | |
| 10/30/2010 | Central State 6 @ Lambuth Eagles 42 | |
| 11/6/2010 | Central State 12 @ Urbana Blue Knights 40 | † |
| 11/13/2010 | Central State 13 @ Stillman Tigers 44 |